FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804415416> ?p ?o ?g. }

• W2804415416 abstract "Exposure to ambient fine particulate matter (PM2.5) correlates with abnormal glucose homeostasis, but the underlying biological mechanism has not been fully understood. The gut microbiota is an emerging crucial player in the homeostatic regulation of glucose metabolism. Few studies have investigated its role in the PM2.5 exposure-induced abnormalities in glucose homeostasis. C57Bl/6J mice were exposed to filtered air (FA) or concentrated ambient PM2.5 (CAP) for 12 months using a versatile aerosol concentration enrichment system (VACES) that was modified for long-term whole-body exposures. Their glucose homeostasis and gut microbiota were examined and analysed by correlation and mediation analysis. Intraperitoneal glucose tolerance test (IPGTT) and insulin tolerance test (ITT) showed that CAP exposure markedly impaired their glucose and insulin tolerance. Faecal microbiota analysis demonstrated that the impairment in glucose homeostasis was coincided with decreased faecal bacterial ACE and Chao-1 estimators (the indexes of community richness), while there was no significant change in all faecal fungal alpha diversity estimators. The Pearson’s correlation analyses showed that the bacterial richness estimators were correlated with glucose and insulin tolerance, and the mediation analyses displayed a significant mediation of CAP exposure-induced glucose intolerance by the alteration in the bacterial Chao-1 estimator. LEfSe analyses revealed 24 bacterial and 21 fungal taxa differential between CAP- and FA-exposed animals. Of these, 14 and 20 bacterial taxa were correlated with IPGTT AUC and ITT AUC, respectively, and 5 fungal taxa were correlated with abnormalities in glucose metabolism. Chronic exposure to PM2.5 causes gut dysbiosis and may subsequently contribute to the development of abnormalities in glucose metabolism." @default.
• W2804415416 created "2018-06-01" @default.
• W2804415416 creator A5001652362 @default.
• W2804415416 creator A5013092108 @default.
• W2804415416 creator A5028316343 @default.
• W2804415416 creator A5031973253 @default.
• W2804415416 creator A5039009774 @default.
• W2804415416 creator A5044742215 @default.
• W2804415416 creator A5047751370 @default.
• W2804415416 creator A5052022256 @default.
• W2804415416 creator A5059006900 @default.
• W2804415416 creator A5064454449 @default.
• W2804415416 date "2018-04-17" @default.
• W2804415416 modified "2023-10-18" @default.
• W2804415416 title "Exposure to concentrated ambient PM2.5 alters the composition of gut microbiota in a murine model" @default.
• W2804415416 cites W1488872869 @default.
• W2804415416 cites W1856033750 @default.
• W2804415416 cites W1989226504 @default.
• W2804415416 cites W2034285706 @default.
• W2804415416 cites W2037274632 @default.
• W2804415416 cites W2038064966 @default.
• W2804415416 cites W2044841374 @default.
• W2804415416 cites W2057411492 @default.
• W2804415416 cites W2064272233 @default.
• W2804415416 cites W2071841602 @default.
• W2804415416 cites W2072970694 @default.
• W2804415416 cites W2086648828 @default.
• W2804415416 cites W2091441026 @default.
• W2804415416 cites W2104890139 @default.
• W2804415416 cites W2130889389 @default.
• W2804415416 cites W2150751323 @default.
• W2804415416 cites W2151522165 @default.
• W2804415416 cites W2152885278 @default.
• W2804415416 cites W2160947363 @default.
• W2804415416 cites W2164888249 @default.
• W2804415416 cites W2167062509 @default.
• W2804415416 cites W2331590652 @default.
• W2804415416 cites W2402894798 @default.
• W2804415416 cites W2408231795 @default.
• W2804415416 cites W2465534016 @default.
• W2804415416 cites W2468194934 @default.
• W2804415416 cites W2549459101 @default.
• W2804415416 cites W2569868417 @default.
• W2804415416 cites W2588619268 @default.
• W2804415416 cites W2592663486 @default.
• W2804415416 cites W2593198741 @default.
• W2804415416 cites W2611742857 @default.
• W2804415416 cites W2751678104 @default.
• W2804415416 cites W2754871715 @default.
• W2804415416 cites W2765468584 @default.
• W2804415416 cites W3121505931 @default.
• W2804415416 cites W4211058450 @default.
• W2804415416 doi "https://doi.org/10.1186/s12989-018-0252-6" @default.
• W2804415416 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5905147" @default.
• W2804415416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29665823" @default.
• W2804415416 hasPublicationYear "2018" @default.
• W2804415416 type Work @default.
• W2804415416 sameAs 2804415416 @default.
• W2804415416 citedByCount "100" @default.
• W2804415416 countsByYear W28044154162018 @default.
• W2804415416 countsByYear W28044154162019 @default.
• W2804415416 countsByYear W28044154162020 @default.
• W2804415416 countsByYear W28044154162021 @default.
• W2804415416 countsByYear W28044154162022 @default.
• W2804415416 countsByYear W28044154162023 @default.
• W2804415416 crossrefType "journal-article" @default.
• W2804415416 hasAuthorship W2804415416A5001652362 @default.
• W2804415416 hasAuthorship W2804415416A5013092108 @default.
• W2804415416 hasAuthorship W2804415416A5028316343 @default.
• W2804415416 hasAuthorship W2804415416A5031973253 @default.
• W2804415416 hasAuthorship W2804415416A5039009774 @default.
• W2804415416 hasAuthorship W2804415416A5044742215 @default.
• W2804415416 hasAuthorship W2804415416A5047751370 @default.
• W2804415416 hasAuthorship W2804415416A5052022256 @default.
• W2804415416 hasAuthorship W2804415416A5059006900 @default.
• W2804415416 hasAuthorship W2804415416A5064454449 @default.
• W2804415416 hasBestOaLocation W28044154161 @default.
• W2804415416 hasConcept C126322002 @default.
• W2804415416 hasConcept C134018914 @default.
• W2804415416 hasConcept C17093226 @default.
• W2804415416 hasConcept C2777165150 @default.
• W2804415416 hasConcept C2777180221 @default.
• W2804415416 hasConcept C2777391703 @default.
• W2804415416 hasConcept C2779306644 @default.
• W2804415416 hasConcept C2780609358 @default.
• W2804415416 hasConcept C2780833929 @default.
• W2804415416 hasConcept C3018667095 @default.
• W2804415416 hasConcept C539455810 @default.
• W2804415416 hasConcept C55493867 @default.
• W2804415416 hasConcept C555293320 @default.
• W2804415416 hasConcept C63645605 @default.
• W2804415416 hasConcept C71924100 @default.
• W2804415416 hasConcept C86803240 @default.
• W2804415416 hasConceptScore W2804415416C126322002 @default.
• W2804415416 hasConceptScore W2804415416C134018914 @default.
• W2804415416 hasConceptScore W2804415416C17093226 @default.
• W2804415416 hasConceptScore W2804415416C2777165150 @default.
• W2804415416 hasConceptScore W2804415416C2777180221 @default.
• W2804415416 hasConceptScore W2804415416C2777391703 @default.
• W2804415416 hasConceptScore W2804415416C2779306644 @default.

• next