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- W2804416990 endingPage "25749" @default.
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- W2804416990 abstract "Anticancer drugs may have proarrhythmic effects including drug-induced QT interval prolongation, which is of particular importance because it can lead to a fatal polymorphic ventricular tachycardia termed torsade de pointes (TdP). QT interval prolongation and TdP are rare life-threatening untoward effects of anticancer therapy, particularly with arsenic trioxides and anthracyclines, and even some novel molecular targeted drugs touted as 'tumor specific'. Several factors that affect myocardial repolarization can further increase the risk of TdP. This article reviews the mechanism of QT interval prolongation, risk factors for TdP and the QT toxicity of anticancer drugs as well as its management. Specific attention should be paid to high-risk populations such as patients with underlying heart diseases, electrolyte imbalance and bradycardia. To minimize the occurrence of QT interval prolongation and TdP, it is advisable to conduct a careful risk factor assessment before antitumor therapy. To this end, several new biomarkers have been introduced to predict TdP triggering and recent studies have pointed out the potential clinical relevance of genetic testing." @default.
- W2804416990 created "2018-06-01" @default.
- W2804416990 creator A5001930754 @default.
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- W2804416990 creator A5049710042 @default.
- W2804416990 creator A5084068635 @default.
- W2804416990 date "2018-05-22" @default.
- W2804416990 modified "2023-10-17" @default.
- W2804416990 title "Anticancer drugs-related QTc prolongation, torsade de pointes and sudden death: current evidence and future research perspectives" @default.
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