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- W2804428835 abstract "An infection with the Human immunodeficiency virus (HIV) is associated with B-cell lymphomas. The incidence of some lymphomas remains elevated in HIV-infected individuals whose immune function has been reconstituted under combined antiretroviral therapy. Its contribution to B-cell oncogenesis cells remains enigmatic. HIV-1 is known to induce an oxidative stress and DNA damage (DD) in infected cells via multiple mechanisms. However, it does not infect B lymphocytes. This contrasts with the viral protein Tat which circulates in the blood of infected individuals and spontaneously penetrates even non infectable cells. We have detected high levels of reactive oxygen species (ROS), mainly from mitochondria, and DDs in B-cells ofpatients. We have thus hypothesized that Tat could induce oxidative DD in B-cells thereby promoting genetic instability and malignant transformation. In B-cells isolated from peripheral blood of healthy donors and incubated in the presence of purified recombinant Tat, an oxidative stress has been induced and the antioxidant capacity was decreased. We propose that the oxidative DNA damage and chromosomal aberrations induced by the Tat protein correspond to novel oncogenic factors that favor the development of B-cell lymphomas in HIV-1 infected individuals." @default.
- W2804428835 created "2018-06-01" @default.
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- W2804428835 date "2018-05-01" @default.
- W2804428835 modified "2023-09-26" @default.
- W2804428835 title "Effects of viral proteins on the nuclear organization of human peripheral blood B-cells" @default.
- W2804428835 doi "https://doi.org/10.1016/j.freeradbiomed.2018.04.448" @default.
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