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- W2804443102 abstract "Abstract Activating mutations in the Wnt pathway drive a variety of cancers, but the specific targets and pathways activated by Wnt ligands are not fully understood. To bridge this knowledge gap, we performed a comprehensive time-course analysis of Wnt-dependent signaling pathways in an orthotopic model of Wnt-addicted pancreatic cancer, using a PORCN inhibitor currently in clinical trials, and validated key results in additional Wnt-addicted models. The analysis of temporal changes following Wnt withdrawal demonstrated direct and indirect regulation of >3,500 Wnt activated genes (23% of the transcriptome). Regulation was both transcriptional via Wnt/β-catenin, and through the modulation of protein abundance of important transcription factors including MYC via Wnt/STOP. Our study identifies a central role of Wnt /β-catenin and Wnt/STOP signaling in controlling ribosomal biogenesis, a key driver of cancer proliferation." @default.
- W2804443102 created "2018-06-01" @default.
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- W2804443102 date "2018-05-20" @default.
- W2804443102 modified "2023-09-30" @default.
- W2804443102 title "Oncogenic Wnt/STOP signaling regulates ribosome biogenesis in vivo" @default.
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- W2804443102 doi "https://doi.org/10.1101/326819" @default.
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