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- W2804443677 abstract "The over-expression of multidrug efflux pumps belonging to the Resistance-Nodulation-Division (RND) superfamily is one of the main causes of multidrug-resistance (MDR) in Gram-negative pathogenic bacteria. AcrB is the most thoroughly studied RND transporter and has functioned as a model for our understanding of efflux-mediated MDR. This multidrug-exporter can recognize and transport a wide range of structurally unrelated compounds (including antibiotics, dyes, bile salts and detergents), while it shows a strict inhibitor specificity. Here we discuss our current knowledge of AcrB, and include recent advances, regarding its structure, mechanism of drug transport, substrate recognition, different intramolecular entry pathways and the drug export driven by remote conformational coupling." @default.
- W2804443677 created "2018-06-01" @default.
- W2804443677 creator A5020678543 @default.
- W2804443677 creator A5052384578 @default.
- W2804443677 date "2018-09-01" @default.
- W2804443677 modified "2023-09-30" @default.
- W2804443677 title "Molecular mechanisms of AcrB-mediated multidrug export" @default.
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- W2804443677 doi "https://doi.org/10.1016/j.resmic.2018.05.005" @default.
- W2804443677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29807096" @default.
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