FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804460675> ?p ?o ?g. }

• W2804460675 endingPage "1651" @default.
• W2804460675 startingPage "1641" @default.
• W2804460675 abstract "Recombinant human bone morphogenic protein-2 (BMP-2)-loaded absorbable collagen sponges (ACS) have been successfully used to enhance bone formation and to induce spinal fusion in humans. However, side effects, such as soft tissue edema and inflammation, have been reported. NEMO binding domain peptide (NBD) inhibits activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a central regulator of immune response. In this study, we investigated NBD's potential to reduce BMP-2-induced soft tissue inflammation without affecting BMP-2-mediated spinal fusion in rat. For evaluation of soft tissue inflammation, ACS containing BMP-2, BMP-2+NBD, NBD, or ACS only were implanted into intramuscular paraspinal sites of 32 rats. At day 2 postsurgery, edema formation at the implant sites was assessed using magnetic resonance imaging. T2-weighted relaxation time (T2-RT) values were increased in the BMP-2 group compared with BMP-2+NBD, NBD, and ACS groups. No difference in T2-RT values was detected between BMP-2+NBD versus NBD and ACS controls. Postsacrifice, histological analysis of the implant-surrounding zones showed increased mononuclear cell infiltration in the BMP-2 group compared with BMP-2+NBD and controls. The presence of BMP-2 increased relative NF-κB binding and gene expression of inflammatory markers, interleukin (IL)1β, IL6, IL18, and chemokine ligand (CCL)2 and CCL3 compared with controls. In the BMP-2+NBD group, cytokine expression was blocked. No differences were found between BMP-2+NBD and control groups. For evaluation of spinal fusion, posterolateral intertransverse lumbar fusion procedures were performed on 16 rats. ACS were loaded with BMP-2 or BMP-2+NBD. After sacrifice at week 12, microcomputed tomographic assessment of the fusion site detected a higher bone volume and reduced trabecular spacing in the BMP-2+NBD group compared with BMP-2. Histological analysis did not show any differences in newly formed bone microarchitecture. In summary, addition of NBD to BMP-2-loaded ACS reduces BMP-2-induced soft tissue edema formation and mononuclear cell infiltration, diminishes NF-κB binding, and thus blocks transcription of NF-κB-regulated cytokines in rat. Furthermore, NBD stimulates bone formation in BMP-2-mediated spinal fusion, possibly through crosstalk of the NF-κB pathway with other pathways. The results of this study might provide the basis to develop new therapeutic bone grafting approaches with combinatory administration of BMP-2 and NBD for spinal fusion." @default.
• W2804460675 created "2018-06-01" @default.
• W2804460675 creator A5021053962 @default.
• W2804460675 creator A5038149542 @default.
• W2804460675 creator A5044399500 @default.
• W2804460675 creator A5051920050 @default.
• W2804460675 creator A5056512178 @default.
• W2804460675 creator A5062772379 @default.
• W2804460675 creator A5063084419 @default.
• W2804460675 creator A5065837145 @default.
• W2804460675 creator A5081116926 @default.
• W2804460675 date "2018-11-01" @default.
• W2804460675 modified "2023-10-01" @default.
• W2804460675 title "Anti-Inflammatory Peptide Attenuates Edema and Promotes BMP-2-Induced Bone Formation in Spine Fusion" @default.
• W2804460675 cites W1522773084 @default.
• W2804460675 cites W1604518916 @default.
• W2804460675 cites W1967937835 @default.
• W2804460675 cites W1970111618 @default.
• W2804460675 cites W1983805610 @default.
• W2804460675 cites W1997732943 @default.
• W2804460675 cites W2002052041 @default.
• W2804460675 cites W2004215940 @default.
• W2804460675 cites W2008390196 @default.
• W2804460675 cites W2008943389 @default.
• W2804460675 cites W2010929693 @default.
• W2804460675 cites W2016531821 @default.
• W2804460675 cites W2020170548 @default.
• W2804460675 cites W2020572230 @default.
• W2804460675 cites W2022351216 @default.
• W2804460675 cites W2030713791 @default.
• W2804460675 cites W2037283077 @default.
• W2804460675 cites W2041620376 @default.
• W2804460675 cites W2045190143 @default.
• W2804460675 cites W2053127116 @default.
• W2804460675 cites W2055763907 @default.
• W2804460675 cites W2061129980 @default.
• W2804460675 cites W2061265481 @default.
• W2804460675 cites W2062520524 @default.
• W2804460675 cites W2072746048 @default.
• W2804460675 cites W2073288077 @default.
• W2804460675 cites W2074645659 @default.
• W2804460675 cites W2078558875 @default.
• W2804460675 cites W2080657810 @default.
• W2804460675 cites W2087833790 @default.
• W2804460675 cites W2089605078 @default.
• W2804460675 cites W2092798278 @default.
• W2804460675 cites W2093547654 @default.
• W2804460675 cites W2123168225 @default.
• W2804460675 cites W2134887638 @default.
• W2804460675 cites W2135679004 @default.
• W2804460675 cites W2139586508 @default.
• W2804460675 cites W2140429278 @default.
• W2804460675 cites W2149511417 @default.
• W2804460675 cites W2149650813 @default.
• W2804460675 cites W2156097368 @default.
• W2804460675 cites W2162469604 @default.
• W2804460675 cites W2261324366 @default.
• W2804460675 cites W2294088832 @default.
• W2804460675 cites W2329311838 @default.
• W2804460675 cites W2335516311 @default.
• W2804460675 cites W2343938601 @default.
• W2804460675 cites W2400360263 @default.
• W2804460675 cites W2757404192 @default.
• W2804460675 cites W2999065750 @default.
• W2804460675 cites W4211090967 @default.
• W2804460675 cites W4379365691 @default.
• W2804460675 doi "https://doi.org/10.1089/ten.tea.2017.0512" @default.
• W2804460675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7063562" @default.
• W2804460675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29766758" @default.
• W2804460675 hasPublicationYear "2018" @default.
• W2804460675 type Work @default.
• W2804460675 sameAs 2804460675 @default.
• W2804460675 citedByCount "18" @default.
• W2804460675 countsByYear W28044606752018 @default.
• W2804460675 countsByYear W28044606752019 @default.
• W2804460675 countsByYear W28044606752020 @default.
• W2804460675 countsByYear W28044606752021 @default.
• W2804460675 countsByYear W28044606752022 @default.
• W2804460675 countsByYear W28044606752023 @default.
• W2804460675 crossrefType "journal-article" @default.
• W2804460675 hasAuthorship W2804460675A5021053962 @default.
• W2804460675 hasAuthorship W2804460675A5038149542 @default.
• W2804460675 hasAuthorship W2804460675A5044399500 @default.
• W2804460675 hasAuthorship W2804460675A5051920050 @default.
• W2804460675 hasAuthorship W2804460675A5056512178 @default.
• W2804460675 hasAuthorship W2804460675A5062772379 @default.
• W2804460675 hasAuthorship W2804460675A5063084419 @default.
• W2804460675 hasAuthorship W2804460675A5065837145 @default.
• W2804460675 hasAuthorship W2804460675A5081116926 @default.
• W2804460675 hasBestOaLocation W28044606752 @default.
• W2804460675 hasConcept C104317684 @default.
• W2804460675 hasConcept C126322002 @default.
• W2804460675 hasConcept C13373296 @default.
• W2804460675 hasConcept C185592680 @default.
• W2804460675 hasConcept C202751555 @default.
• W2804460675 hasConcept C2776914184 @default.
• W2804460675 hasConcept C2778690821 @default.
• W2804460675 hasConcept C30352789 @default.

• next