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- W2804465763 abstract "Natural killer cells (NKs) are abundant in the human decidua, regulating trophoblast invasion and angiogenesis. Several diseases of poor placental development are associated with first pregnancies, so we thus looked to characterize differences in decidual NKs (dNKs) in first versus repeated pregnancies. We discovered a population found in repeated pregnancies, which has a unique transcriptome and epigenetic signature, and is characterized by high expression of the receptors NKG2C and LILRB1. We named these cells Pregnancy Trained decidual NK cells (PTdNKs). PTdNKs have open chromatin around the enhancers of IFNG and VEGFA. Activation of PTdNKs led to increased production and secretion of IFN-γ and VEGFα, with the latter supporting vascular sprouting and tumor growth. The precursors of PTdNKs seem to be found in the endometrium. Because repeated pregnancies are associated with improved placentation, we propose that PTdNKs, which are present primarily in repeated pregnancies, might be involved in proper placentation." @default.
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- W2804465763 date "2018-05-01" @default.
- W2804465763 modified "2023-10-12" @default.
- W2804465763 title "Trained Memory of Human Uterine NK Cells Enhances Their Function in Subsequent Pregnancies" @default.
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- W2804465763 doi "https://doi.org/10.1016/j.immuni.2018.03.030" @default.
- W2804465763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29768178" @default.
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