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- W2804481983 abstract "Goitre is an enlargement of thyroid gland which can be associated with primary thyroid disorders orstimulation of the gland by hormones and other factors. In Indonesia and especially in Bali, increase ofThyroid Carcinoma cases had been associated with either endemic or non endemic goiter. Goitre increases2.5 fold risk of thyroid carcinoma. Goitre may cause diffuse and nodular hyperplasia (either single or multiplenodules). Clonal analysis has been discovered that hyperplasia is considered to be polyclonal proliferation.Monoclonal alterations had also been found in a subset of thyroid nodules that were previously consideredhyperplastic. Alterations of polyclonal to monoclonal pattern was considered as interaction between pasthistory of hyperplastic lesion and genetic predisposition which furthermore forming mutagenic environmentsuch as increases of cell proliferation and also free radicals induce- somatic mutation. Iodine supplementationon endemic goiter related with radioactive iodine content which damaging DNA sequences in the form of RETTRKrearrangement." @default.
- W2804481983 created "2018-06-01" @default.
- W2804481983 creator A5035945628 @default.
- W2804481983 date "2016-11-01" @default.
- W2804481983 modified "2023-09-24" @default.
- W2804481983 title "Goitre as Predisposing Factor of Thyroid Carcinomas" @default.
- W2804481983 hasPublicationYear "2016" @default.
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