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- W2804486871 abstract "CORMs are metal carbonyl complexes that release carbon monoxide, a human signalling molecule with cytoprotective, anti-inflammatory and other beneficial therapeutic effects, in a controlled and targeted way[1]. The antimicrobial properties of CORMs were firstly shown by our group in 2007 [2]. Since then, the bactericidal activity of CORMs against several human pathogens and parasites [3–4], and also as adjuvants of several antibiotics [5], was shown for several pathogens. Additionally, the fact that, in general, CORMs are not toxic to eukaryotic cells makes them a promising new class of antibiotics [6]. In this work, we report a novel approach for the development of a new family of CORMs, based on iterative chemical modifications that potentiate their antimicrobial effect. Several CORMs were prepared and the results on the in vitro anti-infective properties and toxicity profile will be presented and discussed." @default.
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- W2804486871 date "2018-05-01" @default.
- W2804486871 modified "2023-09-27" @default.
- W2804486871 title "Developing a new class of antibiotics – a step closer" @default.
- W2804486871 doi "https://doi.org/10.1016/j.freeradbiomed.2018.04.495" @default.
- W2804486871 hasPublicationYear "2018" @default.
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