FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804489736> ?p ?o ?g. }

• W2804489736 abstract "MicroRNAs (miRNAs/miRs) serve tumor promoting or suppressive roles in different human cancer types, including glioma; however, the regulatory underlying mechanism by which miR-599 affects glioma progression remains largely unknown. The aim of the present study was to investigate the expression of miR-599 in glioma, as well as the underlying regulatory mechanism. Reverse transcription-quantitative polymerase chain reaction and western blot analysis were used to examine mRNA and protein expression, respectively. MTT, wound healing and transwell assays were conducted to study cell proliferation, migration and invasion, respectively. A dual-luciferase reporter gene assay was used to confirm the targeting association between miR-599 and Ras-related protein Rab-27B (hereafter RAB27B). In the present study, miR-599 expression was observed to be significantly downregulated in human glioma tissues and cell lines, when compared with normal brain tissues and normal human astrocyte cells, respectively. Low miR-599 expression was significantly associated with glioma progression. Ectopic expression of miR-599 caused a significant reduction in the proliferation, migration and invasion of U-87MG Uppsala and U251 cells. Bioinformatics analysis and dual-luciferase reporter gene assay data identified that RAB27B was a direct target gene of miR-599. The mRNA and protein expression of RAB27B was significantly downregulated following miR-599 overexpression in U-87MG Uppsala and U251 cells. Rescue experiments demonstrated that RAB27B rescued the miR-599-induced inhibition of glioma cell growth, migration and invasion. In addition, RAB27B expression was significantly upregulated in glioma tissues and cell lines, and the expression levels of RAB27B were inversely correlated with miR-599 levels in glioma tissues; therefore, the present study demonstrated that miR-599 exerts a tumor-suppressive role in glioma progression by targeting RAB27B, indicating that miR-599 may be used as a potential candidate for glioma treatment." @default.
• W2804489736 created "2018-06-01" @default.
• W2804489736 creator A5024090925 @default.
• W2804489736 creator A5041448180 @default.
• W2804489736 creator A5046753601 @default.
• W2804489736 creator A5090610975 @default.
• W2804489736 date "2018-05-16" @default.
• W2804489736 modified "2023-10-16" @default.
• W2804489736 title "MicroRNA‑599 suppresses glioma progression by targeting RAB27B" @default.
• W2804489736 cites W1998153400 @default.
• W2804489736 cites W2014946489 @default.
• W2804489736 cites W2097595532 @default.
• W2804489736 cites W2107277218 @default.
• W2804489736 cites W2116728985 @default.
• W2804489736 cites W2160202949 @default.
• W2804489736 cites W2277661453 @default.
• W2804489736 cites W2280345261 @default.
• W2804489736 cites W2474879897 @default.
• W2804489736 cites W2510174517 @default.
• W2804489736 cites W2521716828 @default.
• W2804489736 cites W2530229693 @default.
• W2804489736 cites W2555949056 @default.
• W2804489736 cites W2563538576 @default.
• W2804489736 cites W2581512105 @default.
• W2804489736 cites W2585484755 @default.
• W2804489736 cites W2614350729 @default.
• W2804489736 cites W2619716020 @default.
• W2804489736 cites W2620951925 @default.
• W2804489736 cites W2621479134 @default.
• W2804489736 cites W2775661709 @default.
• W2804489736 cites W2917837889 @default.
• W2804489736 doi "https://doi.org/10.3892/ol.2018.8727" @default.
• W2804489736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8323010" @default.
• W2804489736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34345302" @default.
• W2804489736 hasPublicationYear "2018" @default.
• W2804489736 type Work @default.
• W2804489736 sameAs 2804489736 @default.
• W2804489736 citedByCount "11" @default.
• W2804489736 countsByYear W28044897362018 @default.
• W2804489736 countsByYear W28044897362019 @default.
• W2804489736 countsByYear W28044897362020 @default.
• W2804489736 countsByYear W28044897362021 @default.
• W2804489736 countsByYear W28044897362022 @default.
• W2804489736 crossrefType "journal-article" @default.
• W2804489736 hasAuthorship W2804489736A5024090925 @default.
• W2804489736 hasAuthorship W2804489736A5041448180 @default.
• W2804489736 hasAuthorship W2804489736A5046753601 @default.
• W2804489736 hasAuthorship W2804489736A5090610975 @default.
• W2804489736 hasBestOaLocation W28044897361 @default.
• W2804489736 hasConcept C104317684 @default.
• W2804489736 hasConcept C11957725 @default.
• W2804489736 hasConcept C145059251 @default.
• W2804489736 hasConcept C1491633281 @default.
• W2804489736 hasConcept C150194340 @default.
• W2804489736 hasConcept C153911025 @default.
• W2804489736 hasConcept C161733203 @default.
• W2804489736 hasConcept C2776415932 @default.
• W2804489736 hasConcept C2778227246 @default.
• W2804489736 hasConcept C2781018059 @default.
• W2804489736 hasConcept C29537977 @default.
• W2804489736 hasConcept C502942594 @default.
• W2804489736 hasConcept C54009773 @default.
• W2804489736 hasConcept C54355233 @default.
• W2804489736 hasConcept C555283112 @default.
• W2804489736 hasConcept C62112901 @default.
• W2804489736 hasConcept C81885089 @default.
• W2804489736 hasConcept C86803240 @default.
• W2804489736 hasConcept C97037327 @default.
• W2804489736 hasConceptScore W2804489736C104317684 @default.
• W2804489736 hasConceptScore W2804489736C11957725 @default.
• W2804489736 hasConceptScore W2804489736C145059251 @default.
• W2804489736 hasConceptScore W2804489736C1491633281 @default.
• W2804489736 hasConceptScore W2804489736C150194340 @default.
• W2804489736 hasConceptScore W2804489736C153911025 @default.
• W2804489736 hasConceptScore W2804489736C161733203 @default.
• W2804489736 hasConceptScore W2804489736C2776415932 @default.
• W2804489736 hasConceptScore W2804489736C2778227246 @default.
• W2804489736 hasConceptScore W2804489736C2781018059 @default.
• W2804489736 hasConceptScore W2804489736C29537977 @default.
• W2804489736 hasConceptScore W2804489736C502942594 @default.
• W2804489736 hasConceptScore W2804489736C54009773 @default.
• W2804489736 hasConceptScore W2804489736C54355233 @default.
• W2804489736 hasConceptScore W2804489736C555283112 @default.
• W2804489736 hasConceptScore W2804489736C62112901 @default.
• W2804489736 hasConceptScore W2804489736C81885089 @default.
• W2804489736 hasConceptScore W2804489736C86803240 @default.
• W2804489736 hasConceptScore W2804489736C97037327 @default.
• W2804489736 hasLocation W28044897361 @default.
• W2804489736 hasLocation W28044897362 @default.
• W2804489736 hasLocation W28044897363 @default.
• W2804489736 hasLocation W28044897364 @default.
• W2804489736 hasOpenAccess W2804489736 @default.
• W2804489736 hasPrimaryLocation W28044897361 @default.
• W2804489736 hasRelatedWork W1978408634 @default.
• W2804489736 hasRelatedWork W2098091396 @default.
• W2804489736 hasRelatedWork W2114037065 @default.
• W2804489736 hasRelatedWork W2495449617 @default.
• W2804489736 hasRelatedWork W2525906185 @default.
• W2804489736 hasRelatedWork W2535293292 @default.
• W2804489736 hasRelatedWork W2757731308 @default.

• next