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• W2804497419 abstract "Sialyl-Tn (STn) is a tumor-associated carbohydrate antigen (TACA) rarely observed on healthy tissues. We synthesized two fully synthetic N-acetyl and N-propionyl STn trimer (triSTn) vaccines possessing a T-helper epitope and a TLR2 agonist, since the clustered STn antigens are highly expressed on many cancer cells. Immunization of both vaccines in mice induced the anti-triSTn IgG antibodies, which recognized triSTn-expressing cell lines PANC-1 and HepG2. The N-propionyl triSTn vaccine induced the triSTn-specific IgGs, while IgGs induced by the N-acetyl triSTn vaccine were less specific. These results illustrated that N-propionyl triSTn is a valuable unnatural TACA for anticancer vaccines." @default.
• W2804497419 created "2018-06-01" @default.
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• W2804497419 date "2018-07-02" @default.
• W2804497419 modified "2023-10-17" @default.
• W2804497419 title "Syntheses and Immunological Evaluation of Self‐Adjuvanting Clustered<i>N</i>‐Acetyl and<i>N</i>‐Propionyl Sialyl‐Tn Combined with a T‐helper Cell Epitope as Antitumor Vaccine Candidates" @default.
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• W2804497419 doi "https://doi.org/10.1002/anie.201804437" @default.
• W2804497419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29768704" @default.
• W2804497419 hasPublicationYear "2018" @default.
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