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• W2804550352 abstract "Abstract The pathophysiology of neuropathic pain generation has not been fully investigated. Previous studies have primarily focused on changes in the properties of single neurons in the brain after nerve injury; however, little is known concerning the role of neuron-to-neuron connections in neuropathic pain pathogenesis. Synaptic transmission potentiation in anterior cingulate cortex (ACC) has been confirmed to be responsible for the formation of neuropathic pain. Thus, analysis of interneuronal connections in the ACC is an important approach for understanding the mechanism of neuropathic pain since it provides information on the potency of synaptic transmission. Here, we recorded membrane potentials from pairs of ACC neurons in anaesthetised rats and found that cross-correlations between pairs of ACC neurons significantly increased after surgery for chronic constriction injury (CCI). Moreover, CCI surgery could also enhance the power spectrum density of lower and higher-frequency membrane oscillations while having no effect on middle-frequency oscillations. The activation of membrane potential synchrony and power spectrum was reversed by the electrical synapse blocker mefloquine and pain behaviour was simultaneously alleviated. Our results may indicate that activation of membrane potential synchrony contributes to generation of neuropathic pain." @default.
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• W2804550352 date "2018-01-26" @default.
• W2804550352 modified "2023-10-12" @default.
• W2804550352 title "Membrane potential synchrony of neurons in anterior cingulate cortex plays a pivotal role in generation of neuropathic pain" @default.
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• W2804550352 doi "https://doi.org/10.1038/s41598-018-20080-2" @default.
• W2804550352 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5785961" @default.
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