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- W2804585019 abstract "Aims: Nerve conduction block using implanted electrodes is being used increasingly for clinical applications. Alternatively, non-invasive electrical nerve block would be beneficial for applications including pain block and muscle spasticity. Here we developed a novel means of non-invasive electrical nerve conduction blockade – transcutaneous direct current block (tDCB) – that produces direct block of nerve conduction. Materials & Methods: In an in vivo rodent model, tDCB produced stable neuromotor blockade of sciatic nerve branches, dependent on stimulus parameters and electrode geometry. Results: Partial-to-complete neuromotor block was achieved in all subjects using tDCB amplitudes at or below 20 mA, and complete block was achieved at amplitudes as low as 6 mA. Conclusions: Our results reveal that neuromotor activity can be rapidly, reliably and reversibly blocked using tDCB." @default.
- W2804585019 created "2018-06-01" @default.
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- W2804585019 date "2018-05-01" @default.
- W2804585019 modified "2023-09-27" @default.
- W2804585019 title "Block of motor nerve conduction via transcutaneous application of direct current" @default.
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- W2804585019 doi "https://doi.org/10.2217/bem-2017-0011" @default.
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