FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804601578> ?p ?o ?g. }

• W2804601578 endingPage "2208" @default.
• W2804601578 startingPage "2195" @default.
• W2804601578 abstract "TP53 mutations occur in many different types of cancers that produce mutant p53 proteins. The mutant p53 proteins have lost wild-type p53 activity and gained new functions that contribute to malignant tumor progression. Different p53 mutations create distinct profiles in loss of wild-type p53 activity and gain of functions. Targeting the consequences generated by the great number of p53 mutations would be extremely complex. Therefore, in this study we used a workaround and took advantage of the fact that mutant p53 cannot bind H2AX. Using this, we developed a new approach to repress the acquisition of mutant p53 functions. We show here that the delivery of a circular RNA circ-Ccnb1 inhibited the function of three p53 mutations. By microarray analysis and real-time PCR, we detected decreased circ-Ccnb1 expression levels in patients bearing breast carcinoma. Ectopic delivery of circ-Ccnb1 inhibited tumor growth and extended mouse viability. Using proteomics, we found that circ-Ccnb1 precipitated p53 in p53 wild-type cells, but instead precipitated Bclaf1 in p53 mutant cells. Further experiments showed that H2AX serves as a bridge, linking the interaction of circ-Ccnb1 and wild-type p53, thus allowing Bclaf1 to bind Bcl2 resulting in cell survival. In the p53 mutant cells, circ-Ccnb1 formed a complex with H2AX and Bclaf1, resulting in the induction of cell death. We found that this occurred in three p53 mutations. These results shed light on the possible development of new approaches to inhibit the malignancy of p53 mutations." @default.
• W2804601578 created "2018-06-01" @default.
• W2804601578 creator A5004402528 @default.
• W2804601578 creator A5008516074 @default.
• W2804601578 creator A5021527084 @default.
• W2804601578 creator A5024711370 @default.
• W2804601578 creator A5028932344 @default.
• W2804601578 creator A5034704242 @default.
• W2804601578 creator A5038014937 @default.
• W2804601578 creator A5039118504 @default.
• W2804601578 creator A5049940232 @default.
• W2804601578 creator A5057909367 @default.
• W2804601578 creator A5061351930 @default.
• W2804601578 creator A5066594360 @default.
• W2804601578 creator A5067165216 @default.
• W2804601578 creator A5080035617 @default.
• W2804601578 creator A5083471411 @default.
• W2804601578 creator A5084918710 @default.
• W2804601578 creator A5088884825 @default.
• W2804601578 creator A5089966579 @default.
• W2804601578 date "2018-05-23" @default.
• W2804601578 modified "2023-10-15" @default.
• W2804601578 title "Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1" @default.
• W2804601578 cites W1678036318 @default.
• W2804601578 cites W1854469936 @default.
• W2804601578 cites W1966411071 @default.
• W2804601578 cites W1968075505 @default.
• W2804601578 cites W1974930666 @default.
• W2804601578 cites W1985271346 @default.
• W2804601578 cites W1991082489 @default.
• W2804601578 cites W1995068068 @default.
• W2804601578 cites W2004446628 @default.
• W2804601578 cites W2005715240 @default.
• W2804601578 cites W2017768662 @default.
• W2804601578 cites W2027409966 @default.
• W2804601578 cites W2033093495 @default.
• W2804601578 cites W2034882416 @default.
• W2804601578 cites W2041908101 @default.
• W2804601578 cites W2046324232 @default.
• W2804601578 cites W2055493067 @default.
• W2804601578 cites W2058835062 @default.
• W2804601578 cites W2066930988 @default.
• W2804601578 cites W2071714380 @default.
• W2804601578 cites W2074707854 @default.
• W2804601578 cites W2088441464 @default.
• W2804601578 cites W2101086441 @default.
• W2804601578 cites W2116498086 @default.
• W2804601578 cites W2119493141 @default.
• W2804601578 cites W2124821475 @default.
• W2804601578 cites W2129562311 @default.
• W2804601578 cites W2131105369 @default.
• W2804601578 cites W2133141667 @default.
• W2804601578 cites W2219781244 @default.
• W2804601578 cites W2266356262 @default.
• W2804601578 cites W2266420598 @default.
• W2804601578 cites W2290820108 @default.
• W2804601578 cites W2297315363 @default.
• W2804601578 cites W2316171452 @default.
• W2804601578 cites W2325557141 @default.
• W2804601578 cites W2398392409 @default.
• W2804601578 cites W2511152819 @default.
• W2804601578 cites W2557141539 @default.
• W2804601578 cites W2563970809 @default.
• W2804601578 cites W2573702131 @default.
• W2804601578 cites W2588485809 @default.
• W2804601578 cites W2601436215 @default.
• W2804601578 cites W2602367484 @default.
• W2804601578 cites W2605112026 @default.
• W2804601578 cites W2624817122 @default.
• W2804601578 cites W2626686215 @default.
• W2804601578 cites W2744268790 @default.
• W2804601578 cites W2754041968 @default.
• W2804601578 cites W2762029443 @default.
• W2804601578 doi "https://doi.org/10.1038/s41418-018-0115-6" @default.
• W2804601578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6261950" @default.
• W2804601578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29795334" @default.
• W2804601578 hasPublicationYear "2018" @default.
• W2804601578 type Work @default.
• W2804601578 sameAs 2804601578 @default.
• W2804601578 citedByCount "92" @default.
• W2804601578 countsByYear W28046015782018 @default.
• W2804601578 countsByYear W28046015782019 @default.
• W2804601578 countsByYear W28046015782020 @default.
• W2804601578 countsByYear W28046015782021 @default.
• W2804601578 countsByYear W28046015782022 @default.
• W2804601578 countsByYear W28046015782023 @default.
• W2804601578 crossrefType "journal-article" @default.
• W2804601578 hasAuthorship W2804601578A5004402528 @default.
• W2804601578 hasAuthorship W2804601578A5008516074 @default.
• W2804601578 hasAuthorship W2804601578A5021527084 @default.
• W2804601578 hasAuthorship W2804601578A5024711370 @default.
• W2804601578 hasAuthorship W2804601578A5028932344 @default.
• W2804601578 hasAuthorship W2804601578A5034704242 @default.
• W2804601578 hasAuthorship W2804601578A5038014937 @default.
• W2804601578 hasAuthorship W2804601578A5039118504 @default.
• W2804601578 hasAuthorship W2804601578A5049940232 @default.
• W2804601578 hasAuthorship W2804601578A5057909367 @default.
• W2804601578 hasAuthorship W2804601578A5061351930 @default.

• next