FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804663669> ?p ?o ?g. }

• W2804663669 endingPage "e201800052" @default.
• W2804663669 startingPage "e201800052" @default.
• W2804663669 abstract "Cellular RNA abundance is determined by both RNA transcription and decay. Therefore, change in RNA abundance, which can drive phenotypic diversity between different species, could arise from genetic variants affecting either process. However, previous studies in the evolution of RNA expression have been largely focused on transcription. Here, to globally investigate the effects of cis -regulatory divergence on RNA decay in mammals for the first time, we quantified allele-specific differences in RNA decay rates (ASD) in an F1 hybrid mouse. Out of 8,815 genes with sufficient data, we identified 621 genes exhibiting significant cis -divergence. Systematic analysis of these genes revealed that the genetic variants affecting microRNA binding and RNA secondary structures contribute to the observed divergences. Finally, we demonstrated that although the divergences in RNA abundance were predominantly determined by allelic differences in RNA transcription, most genes with significant ASD did not exhibit significant difference in RNA abundance. For these genes, the apparently compensatory effect between the allelic differences in RNA transcription and ASD suggests that changes in RNA decay could serve as important means to stabilize RNA abundances during mammalian evolution." @default.
• W2804663669 created "2018-06-01" @default.
• W2804663669 creator A5015935509 @default.
• W2804663669 creator A5016730202 @default.
• W2804663669 creator A5030668248 @default.
• W2804663669 creator A5037696066 @default.
• W2804663669 creator A5054722650 @default.
• W2804663669 date "2018-05-01" @default.
• W2804663669 modified "2023-10-12" @default.
• W2804663669 title "Pervasive allele-specific regulation on RNA decay in hybrid mice" @default.
• W2804663669 cites W144423133 @default.
• W2804663669 cites W1480207859 @default.
• W2804663669 cites W1901718466 @default.
• W2804663669 cites W1951632364 @default.
• W2804663669 cites W1964169827 @default.
• W2804663669 cites W1969836160 @default.
• W2804663669 cites W1972255859 @default.
• W2804663669 cites W1974454061 @default.
• W2804663669 cites W1976415203 @default.
• W2804663669 cites W1981506621 @default.
• W2804663669 cites W1993616000 @default.
• W2804663669 cites W2004128549 @default.
• W2804663669 cites W2005501593 @default.
• W2804663669 cites W2014185871 @default.
• W2804663669 cites W2018590530 @default.
• W2804663669 cites W2026570544 @default.
• W2804663669 cites W2026771976 @default.
• W2804663669 cites W2035359863 @default.
• W2804663669 cites W2039746015 @default.
• W2804663669 cites W2043600630 @default.
• W2804663669 cites W2044271687 @default.
• W2804663669 cites W2064036807 @default.
• W2804663669 cites W2067197082 @default.
• W2804663669 cites W2080532845 @default.
• W2804663669 cites W2086561953 @default.
• W2804663669 cites W2088860412 @default.
• W2804663669 cites W2092126428 @default.
• W2804663669 cites W2097065948 @default.
• W2804663669 cites W2099029060 @default.
• W2804663669 cites W2105598902 @default.
• W2804663669 cites W2116996710 @default.
• W2804663669 cites W2117031702 @default.
• W2804663669 cites W2120456037 @default.
• W2804663669 cites W2121413434 @default.
• W2804663669 cites W2124164469 @default.
• W2804663669 cites W2126204672 @default.
• W2804663669 cites W2128551987 @default.
• W2804663669 cites W2132522861 @default.
• W2804663669 cites W2132885646 @default.
• W2804663669 cites W2134199796 @default.
• W2804663669 cites W2146564033 @default.
• W2804663669 cites W2153276140 @default.
• W2804663669 cites W2153401206 @default.
• W2804663669 cites W2158434164 @default.
• W2804663669 cites W2165246239 @default.
• W2804663669 cites W2298977477 @default.
• W2804663669 cites W2415723512 @default.
• W2804663669 cites W2495238549 @default.
• W2804663669 cites W2739717808 @default.
• W2804663669 cites W2765387508 @default.
• W2804663669 doi "https://doi.org/10.26508/lsa.201800052" @default.
• W2804663669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6238540" @default.
• W2804663669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30456349" @default.
• W2804663669 hasPublicationYear "2018" @default.
• W2804663669 type Work @default.
• W2804663669 sameAs 2804663669 @default.
• W2804663669 citedByCount "9" @default.
• W2804663669 countsByYear W28046636692018 @default.
• W2804663669 countsByYear W28046636692019 @default.
• W2804663669 countsByYear W28046636692020 @default.
• W2804663669 countsByYear W28046636692021 @default.
• W2804663669 countsByYear W28046636692022 @default.
• W2804663669 countsByYear W28046636692023 @default.
• W2804663669 crossrefType "journal-article" @default.
• W2804663669 hasAuthorship W2804663669A5015935509 @default.
• W2804663669 hasAuthorship W2804663669A5016730202 @default.
• W2804663669 hasAuthorship W2804663669A5030668248 @default.
• W2804663669 hasAuthorship W2804663669A5037696066 @default.
• W2804663669 hasAuthorship W2804663669A5054722650 @default.
• W2804663669 hasBestOaLocation W28046636691 @default.
• W2804663669 hasConcept C104317684 @default.
• W2804663669 hasConcept C105580179 @default.
• W2804663669 hasConcept C138885662 @default.
• W2804663669 hasConcept C145059251 @default.
• W2804663669 hasConcept C150194340 @default.
• W2804663669 hasConcept C179926584 @default.
• W2804663669 hasConcept C180754005 @default.
• W2804663669 hasConcept C194993378 @default.
• W2804663669 hasConcept C41895202 @default.
• W2804663669 hasConcept C54355233 @default.
• W2804663669 hasConcept C67705224 @default.
• W2804663669 hasConcept C86803240 @default.
• W2804663669 hasConceptScore W2804663669C104317684 @default.
• W2804663669 hasConceptScore W2804663669C105580179 @default.
• W2804663669 hasConceptScore W2804663669C138885662 @default.
• W2804663669 hasConceptScore W2804663669C145059251 @default.
• W2804663669 hasConceptScore W2804663669C150194340 @default.
• W2804663669 hasConceptScore W2804663669C179926584 @default.

• next