FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W280467041> ?p ?o ?g. }

• W280467041 endingPage "519" @default.
• W280467041 startingPage "507" @default.
• W280467041 abstract "Background Formation of transmembrane ion channels by hepatitis C virus (HCV) p7 and abrogation of channel function by amantadine was demonstrated in vitro. The relevance of HCV p7 amino acid (aa) variations for response to antiviral therapy with amantadine is unknown. Methods HCV p7 was sequenced in 86 individuals who were infected with HCV genotype 1. Thirty-six of 86 patients received amantadine within an interferon-α (IFN-α)-based antiviral therapy. Helical wheel modelling for HCV p7 was performed. Results No significant correlation of overall aa variations within HCV p7 was observed with response to IFN-α-based therapy with amantadine in HCV genotype 1a/b infected patients. When analysis was restricted to non-conservative aa variations, a higher number of aa substitutions within complete HCV p7 and transmem-brane helix 2 was associated with non-response in HCV-1b-infected patients receiving therapy with amantadine ( P=0.015 and P=0.037, respectively), without amantadine ( P=0.106 and P=0.118, respectively), and in the total cohort of HCV-1b-infected patients ( P=0.00007 and P=0.011, respectively). Furthermore, substitution L20F was observed more often in non-responders than responders with HCV-1b infection and therapy with amantadine ( P=0.099). By in silico modelling, aa 20 was located toward the p7 channel lumen. Substitution L20F may impair amantadine action by altering the shape of the ion channel pore. Conclusion Substitution L20F within HCV p7 may be associated with non-response to combination therapy specifically with amantadine in HCV-1b-infected patients. Non-responders with HCV-1b infection showed higher numbers of non-conservative aa variations within HCV p7 than responders, irrespective of the application of amantadine." @default.
• W280467041 created "2016-06-24" @default.
• W280467041 creator A5010290985 @default.
• W280467041 creator A5010474616 @default.
• W280467041 creator A5016181694 @default.
• W280467041 creator A5023556977 @default.
• W280467041 creator A5045504446 @default.
• W280467041 creator A5059027618 @default.
• W280467041 creator A5065285414 @default.
• W280467041 creator A5068329276 @default.
• W280467041 creator A5070817587 @default.
• W280467041 creator A5075688194 @default.
• W280467041 creator A5079573149 @default.
• W280467041 creator A5090681716 @default.
• W280467041 date "2005-05-01" @default.
• W280467041 modified "2023-10-10" @default.
• W280467041 title "Amino Acid Variations in Hepatitis C Virus P7 and Sensitivity to Antiviral Combination Therapy with Amantadine in Chronic Hepatitis C" @default.
• W280467041 cites W1536496588 @default.
• W280467041 cites W1965019049 @default.
• W280467041 cites W1968463429 @default.
• W280467041 cites W1971792395 @default.
• W280467041 cites W1972065621 @default.
• W280467041 cites W1976672753 @default.
• W280467041 cites W1982168682 @default.
• W280467041 cites W1994373739 @default.
• W280467041 cites W2005544093 @default.
• W280467041 cites W2007326444 @default.
• W280467041 cites W2015336471 @default.
• W280467041 cites W2022222874 @default.
• W280467041 cites W2027545702 @default.
• W280467041 cites W2030441312 @default.
• W280467041 cites W2043472052 @default.
• W280467041 cites W2047703023 @default.
• W280467041 cites W2050997685 @default.
• W280467041 cites W2052460379 @default.
• W280467041 cites W2056237446 @default.
• W280467041 cites W2057040842 @default.
• W280467041 cites W2058292477 @default.
• W280467041 cites W2058596298 @default.
• W280467041 cites W2066068032 @default.
• W280467041 cites W2066705292 @default.
• W280467041 cites W2071136569 @default.
• W280467041 cites W2073140843 @default.
• W280467041 cites W2073561242 @default.
• W280467041 cites W2092798016 @default.
• W280467041 cites W2110309669 @default.
• W280467041 cites W2111909811 @default.
• W280467041 cites W2112876622 @default.
• W280467041 cites W2124528668 @default.
• W280467041 cites W2127685726 @default.
• W280467041 cites W2131573378 @default.
• W280467041 cites W2131611074 @default.
• W280467041 cites W2133249965 @default.
• W280467041 cites W2139058244 @default.
• W280467041 cites W2146692015 @default.
• W280467041 cites W2146883389 @default.
• W280467041 cites W2152793674 @default.
• W280467041 cites W2162029157 @default.
• W280467041 cites W2162316896 @default.
• W280467041 cites W2165495076 @default.
• W280467041 cites W2168355544 @default.
• W280467041 cites W4239073631 @default.
• W280467041 doi "https://doi.org/10.1177/135965350601100408" @default.
• W280467041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16856625" @default.
• W280467041 hasPublicationYear "2005" @default.
• W280467041 type Work @default.
• W280467041 sameAs 280467041 @default.
• W280467041 citedByCount "35" @default.
• W280467041 countsByYear W2804670412013 @default.
• W280467041 countsByYear W2804670412014 @default.
• W280467041 countsByYear W2804670412015 @default.
• W280467041 countsByYear W2804670412016 @default.
• W280467041 countsByYear W2804670412018 @default.
• W280467041 countsByYear W2804670412019 @default.
• W280467041 countsByYear W2804670412020 @default.
• W280467041 countsByYear W2804670412021 @default.
• W280467041 crossrefType "journal-article" @default.
• W280467041 hasAuthorship W280467041A5010290985 @default.
• W280467041 hasAuthorship W280467041A5010474616 @default.
• W280467041 hasAuthorship W280467041A5016181694 @default.
• W280467041 hasAuthorship W280467041A5023556977 @default.
• W280467041 hasAuthorship W280467041A5045504446 @default.
• W280467041 hasAuthorship W280467041A5059027618 @default.
• W280467041 hasAuthorship W280467041A5065285414 @default.
• W280467041 hasAuthorship W280467041A5068329276 @default.
• W280467041 hasAuthorship W280467041A5070817587 @default.
• W280467041 hasAuthorship W280467041A5075688194 @default.
• W280467041 hasAuthorship W280467041A5079573149 @default.
• W280467041 hasAuthorship W280467041A5090681716 @default.
• W280467041 hasBestOaLocation W2804670411 @default.
• W280467041 hasConcept C126322002 @default.
• W280467041 hasConcept C159047783 @default.
• W280467041 hasConcept C2522874641 @default.
• W280467041 hasConcept C2776408679 @default.
• W280467041 hasConcept C2776455275 @default.
• W280467041 hasConcept C2776999253 @default.
• W280467041 hasConcept C2777374534 @default.
• W280467041 hasConcept C2777546802 @default.

• next