FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804676875> ?p ?o ?g. }

• W2804676875 endingPage "F511" @default.
• W2804676875 startingPage "F503" @default.
• W2804676875 abstract "G protein pathway suppressor 2 (GPS2) is a multifunctional protein and transcriptional regulation factor that is involved in the G protein MAPK signaling pathway. It has been shown that the MAPK signaling pathway plays an important role in the regulation of renal large-conductance Ca 2+ -activated potassium (BK) channels. In this study, we investigated the effects of GPS2 on BK channel activity and protein expression. In human embryonic kidney (HEK) BK stably expressing cells transfected with either GPS2 or its vector control, a single-cell recording showed that GPS2 significantly increased BK channel activity ( NP o ), increasing BK open probability ( P o ), and channel number ( N) compared with the control. In Cos-7 cells and HEK 293 T cells, GPS2 overexpression significantly enhanced the total protein expression of BK in a dose-dependent manner. Knockdown of GPS2 expression significantly decreased BK protein expression, while increasing ERK1/2 phosphorylation. Knockdown of ERK1/2 expression reversed the GPS2 siRNA-mediated inhibition of BK protein expression in Cos-7 cells. Pretreatments of Cos-7 cells with either the lysosomal inhibitor bafilomycin A1 or the proteasomal inhibitor MG132 partially reversed the inhibitory effects of GPS2 siRNA on BK protein expression. In addition, feeding a high-potassium diet significantly increased both GPS2 and BK protein abundance in mice. These data suggest that GPS2 enhances BK channel activity and its protein expression by reducing ERK1/2 signaling-mediated degradation of the channel." @default.
• W2804676875 created "2018-06-01" @default.
• W2804676875 creator A5000922434 @default.
• W2804676875 creator A5012797990 @default.
• W2804676875 creator A5022684433 @default.
• W2804676875 creator A5027985963 @default.
• W2804676875 creator A5032437498 @default.
• W2804676875 creator A5050263809 @default.
• W2804676875 creator A5052121797 @default.
• W2804676875 creator A5053967516 @default.
• W2804676875 creator A5055789447 @default.
• W2804676875 creator A5068666714 @default.
• W2804676875 creator A5071762112 @default.
• W2804676875 date "2018-09-01" @default.
• W2804676875 modified "2023-09-28" @default.
• W2804676875 title "G protein pathway suppressor 2 enhanced the renal large-conductance Ca²⁺-activated potassium channel expression via inhibiting ERK1/2 signaling pathway" @default.
• W2804676875 cites W1487242600 @default.
• W2804676875 cites W1530607424 @default.
• W2804676875 cites W1964512347 @default.
• W2804676875 cites W1965034333 @default.
• W2804676875 cites W1973435804 @default.
• W2804676875 cites W1974997331 @default.
• W2804676875 cites W1979487838 @default.
• W2804676875 cites W1979646226 @default.
• W2804676875 cites W1981555538 @default.
• W2804676875 cites W1989490275 @default.
• W2804676875 cites W1991860504 @default.
• W2804676875 cites W1992260558 @default.
• W2804676875 cites W1993807664 @default.
• W2804676875 cites W1998719957 @default.
• W2804676875 cites W2004761986 @default.
• W2804676875 cites W2005178989 @default.
• W2804676875 cites W2007933399 @default.
• W2804676875 cites W2014968048 @default.
• W2804676875 cites W2019945905 @default.
• W2804676875 cites W2021958245 @default.
• W2804676875 cites W2023033897 @default.
• W2804676875 cites W2025213989 @default.
• W2804676875 cites W2026089352 @default.
• W2804676875 cites W2028224654 @default.
• W2804676875 cites W2029199485 @default.
• W2804676875 cites W2038621068 @default.
• W2804676875 cites W2048644561 @default.
• W2804676875 cites W2048888251 @default.
• W2804676875 cites W2050767894 @default.
• W2804676875 cites W2079833232 @default.
• W2804676875 cites W2084903350 @default.
• W2804676875 cites W2090437600 @default.
• W2804676875 cites W2096921737 @default.
• W2804676875 cites W2098577403 @default.
• W2804676875 cites W2102426153 @default.
• W2804676875 cites W2104313154 @default.
• W2804676875 cites W2107362018 @default.
• W2804676875 cites W2115446838 @default.
• W2804676875 cites W2135944883 @default.
• W2804676875 cites W2141228008 @default.
• W2804676875 cites W2141832664 @default.
• W2804676875 cites W2144633944 @default.
• W2804676875 cites W2145991777 @default.
• W2804676875 cites W2146164120 @default.
• W2804676875 cites W2147607080 @default.
• W2804676875 cites W2149790768 @default.
• W2804676875 cites W2157906583 @default.
• W2804676875 cites W2159130523 @default.
• W2804676875 cites W2168237435 @default.
• W2804676875 cites W2182749815 @default.
• W2804676875 cites W2400875929 @default.
• W2804676875 cites W4234980549 @default.
• W2804676875 cites W4256476580 @default.
• W2804676875 doi "https://doi.org/10.1152/ajprenal.00041.2018" @default.
• W2804676875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29767559" @default.
• W2804676875 hasPublicationYear "2018" @default.
• W2804676875 type Work @default.
• W2804676875 sameAs 2804676875 @default.
• W2804676875 citedByCount "4" @default.
• W2804676875 countsByYear W28046768752020 @default.
• W2804676875 countsByYear W28046768752022 @default.
• W2804676875 countsByYear W28046768752023 @default.
• W2804676875 crossrefType "journal-article" @default.
• W2804676875 hasAuthorship W2804676875A5000922434 @default.
• W2804676875 hasAuthorship W2804676875A5012797990 @default.
• W2804676875 hasAuthorship W2804676875A5022684433 @default.
• W2804676875 hasAuthorship W2804676875A5027985963 @default.
• W2804676875 hasAuthorship W2804676875A5032437498 @default.
• W2804676875 hasAuthorship W2804676875A5050263809 @default.
• W2804676875 hasAuthorship W2804676875A5052121797 @default.
• W2804676875 hasAuthorship W2804676875A5053967516 @default.
• W2804676875 hasAuthorship W2804676875A5055789447 @default.
• W2804676875 hasAuthorship W2804676875A5068666714 @default.
• W2804676875 hasAuthorship W2804676875A5071762112 @default.
• W2804676875 hasBestOaLocation W28046768751 @default.
• W2804676875 hasConcept C104317684 @default.
• W2804676875 hasConcept C134018914 @default.
• W2804676875 hasConcept C153911025 @default.
• W2804676875 hasConcept C173396325 @default.
• W2804676875 hasConcept C174510640 @default.
• W2804676875 hasConcept C185592680 @default.
• W2804676875 hasConcept C25602115 @default.

• next