Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804677722> ?p ?o ?g. }
- W2804677722 endingPage "9289" @default.
- W2804677722 startingPage "9284" @default.
- W2804677722 abstract "Venetoclax (ABT-199) and idasanutlin (RG7388) are efficient anticancer drugs targeting two essential apoptosis markers, Bcl-2 and MDM2, respectively. Recent studies have shown that the combination of these two drugs leads to remarkable enhancement of anticancer efficacy, both in vitro and in vivo. In an attempt to disclose the relationships of their protein targets, competitive affinity-based proteome profiling coupled with bioimaging was employed to characterize their protein targets in the same cancer cell line and tumor tissue. A series of protein hits, including ITPR1, GSR, RER1, PDIA3, Apoa1, and Tnfrsf17 were simultaneously identified by pull-down/LC-MS/MS with the two sets of affinity-based probes. Dual imaging was successfully carried out, with the simultaneous detection of Bcl-2 and MDM2 expression in various cancer cells. This could facilitate the novel diagnostic and therapeutic strategies of dual targeting of Bcl-2/MDM2." @default.
- W2804677722 created "2018-06-01" @default.
- W2804677722 creator A5000012249 @default.
- W2804677722 creator A5001466305 @default.
- W2804677722 creator A5010636074 @default.
- W2804677722 creator A5012131365 @default.
- W2804677722 creator A5028780184 @default.
- W2804677722 creator A5055546418 @default.
- W2804677722 creator A5058965019 @default.
- W2804677722 creator A5061683314 @default.
- W2804677722 creator A5063569282 @default.
- W2804677722 creator A5078325861 @default.
- W2804677722 date "2018-06-25" @default.
- W2804677722 modified "2023-10-10" @default.
- W2804677722 title "Cell‐ and Tissue‐Based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin" @default.
- W2804677722 cites W1944656365 @default.
- W2804677722 cites W1989344633 @default.
- W2804677722 cites W1991167758 @default.
- W2804677722 cites W1997800761 @default.
- W2804677722 cites W2033122170 @default.
- W2804677722 cites W2033425579 @default.
- W2804677722 cites W2085463908 @default.
- W2804677722 cites W2103520347 @default.
- W2804677722 cites W2118812289 @default.
- W2804677722 cites W2133795104 @default.
- W2804677722 cites W2170776626 @default.
- W2804677722 cites W2172242534 @default.
- W2804677722 cites W2174847205 @default.
- W2804677722 cites W2175756712 @default.
- W2804677722 cites W2195443468 @default.
- W2804677722 cites W2216704942 @default.
- W2804677722 cites W2258448753 @default.
- W2804677722 cites W2295721179 @default.
- W2804677722 cites W2300566088 @default.
- W2804677722 cites W2334130133 @default.
- W2804677722 cites W2335754604 @default.
- W2804677722 cites W2475371777 @default.
- W2804677722 cites W2553250095 @default.
- W2804677722 cites W2575838842 @default.
- W2804677722 cites W2626452878 @default.
- W2804677722 cites W2672830740 @default.
- W2804677722 cites W2726242674 @default.
- W2804677722 cites W2731231330 @default.
- W2804677722 cites W2773114573 @default.
- W2804677722 cites W4247270689 @default.
- W2804677722 cites W4253522783 @default.
- W2804677722 cites W4253767636 @default.
- W2804677722 doi "https://doi.org/10.1002/anie.201802003" @default.
- W2804677722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29768700" @default.
- W2804677722 hasPublicationYear "2018" @default.
- W2804677722 type Work @default.
- W2804677722 sameAs 2804677722 @default.
- W2804677722 citedByCount "31" @default.
- W2804677722 countsByYear W28046777222018 @default.
- W2804677722 countsByYear W28046777222019 @default.
- W2804677722 countsByYear W28046777222020 @default.
- W2804677722 countsByYear W28046777222021 @default.
- W2804677722 countsByYear W28046777222022 @default.
- W2804677722 countsByYear W28046777222023 @default.
- W2804677722 crossrefType "journal-article" @default.
- W2804677722 hasAuthorship W2804677722A5000012249 @default.
- W2804677722 hasAuthorship W2804677722A5001466305 @default.
- W2804677722 hasAuthorship W2804677722A5010636074 @default.
- W2804677722 hasAuthorship W2804677722A5012131365 @default.
- W2804677722 hasAuthorship W2804677722A5028780184 @default.
- W2804677722 hasAuthorship W2804677722A5055546418 @default.
- W2804677722 hasAuthorship W2804677722A5058965019 @default.
- W2804677722 hasAuthorship W2804677722A5061683314 @default.
- W2804677722 hasAuthorship W2804677722A5063569282 @default.
- W2804677722 hasAuthorship W2804677722A5078325861 @default.
- W2804677722 hasConcept C104317684 @default.
- W2804677722 hasConcept C104397665 @default.
- W2804677722 hasConcept C150903083 @default.
- W2804677722 hasConcept C185592680 @default.
- W2804677722 hasConcept C190283241 @default.
- W2804677722 hasConcept C202751555 @default.
- W2804677722 hasConcept C203014093 @default.
- W2804677722 hasConcept C207001950 @default.
- W2804677722 hasConcept C2776192174 @default.
- W2804677722 hasConcept C2777938653 @default.
- W2804677722 hasConcept C2778461978 @default.
- W2804677722 hasConcept C2779675984 @default.
- W2804677722 hasConcept C46111723 @default.
- W2804677722 hasConcept C502942594 @default.
- W2804677722 hasConcept C55493867 @default.
- W2804677722 hasConcept C70721500 @default.
- W2804677722 hasConcept C86803240 @default.
- W2804677722 hasConceptScore W2804677722C104317684 @default.
- W2804677722 hasConceptScore W2804677722C104397665 @default.
- W2804677722 hasConceptScore W2804677722C150903083 @default.
- W2804677722 hasConceptScore W2804677722C185592680 @default.
- W2804677722 hasConceptScore W2804677722C190283241 @default.
- W2804677722 hasConceptScore W2804677722C202751555 @default.
- W2804677722 hasConceptScore W2804677722C203014093 @default.
- W2804677722 hasConceptScore W2804677722C207001950 @default.
- W2804677722 hasConceptScore W2804677722C2776192174 @default.
- W2804677722 hasConceptScore W2804677722C2777938653 @default.
- W2804677722 hasConceptScore W2804677722C2778461978 @default.