Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804717872> ?p ?o ?g. }
- W2804717872 abstract "Summary Following injury, the mammalian spinal cord forms a glial scar and fails to regenerate. In contrast, spinal cord tissue of vertebrate fish regenerates and restores function. Cord transection in zebrafish ( Danio rerio ) initially causes paralysis and neural cell death, with subsequent ependymal glial proliferation, extension of bipolar glia across the lesion, and neurogenesis. Axons extending from spared and nascent neurons along trans-lesional glial bridges restore functional connectivity. Here we report that glucocorticoids directly target the regeneration supporting changes in ependymal glia to inhibit neural repair. This effect is independent of hematogenic immune cells or microglia. Furthermore, glucocorticoid receptor signaling in ependymal glia is inversely regulated in rat models of spinal cord injury compared to zebrafish. The blockade of neural regeneration by glucocorticoids via a direct effect on ependymal glia has important clinical implications concerning the putative therapeutic benefit of corticosteroids in early management of spinal cord injury." @default.
- W2804717872 created "2018-06-01" @default.
- W2804717872 creator A5002348228 @default.
- W2804717872 creator A5008279566 @default.
- W2804717872 creator A5026261579 @default.
- W2804717872 creator A5050616644 @default.
- W2804717872 creator A5054005941 @default.
- W2804717872 creator A5055122406 @default.
- W2804717872 creator A5071188181 @default.
- W2804717872 creator A5072005666 @default.
- W2804717872 creator A5073318993 @default.
- W2804717872 date "2018-05-25" @default.
- W2804717872 modified "2023-09-23" @default.
- W2804717872 title "Glucocorticoid Regulation of Ependymal Glia and Regenerative Potential after Spinal Cord Injury" @default.
- W2804717872 cites W1602000534 @default.
- W2804717872 cites W1963898493 @default.
- W2804717872 cites W1970158133 @default.
- W2804717872 cites W1974506021 @default.
- W2804717872 cites W1976517931 @default.
- W2804717872 cites W1984737307 @default.
- W2804717872 cites W1985728385 @default.
- W2804717872 cites W1999997856 @default.
- W2804717872 cites W2003232848 @default.
- W2804717872 cites W2010819505 @default.
- W2804717872 cites W2013971533 @default.
- W2804717872 cites W2016742969 @default.
- W2804717872 cites W2031649134 @default.
- W2804717872 cites W2033048030 @default.
- W2804717872 cites W2044045263 @default.
- W2804717872 cites W2052207288 @default.
- W2804717872 cites W2054934521 @default.
- W2804717872 cites W2057806637 @default.
- W2804717872 cites W2063337445 @default.
- W2804717872 cites W2072310902 @default.
- W2804717872 cites W2073154435 @default.
- W2804717872 cites W2077538738 @default.
- W2804717872 cites W2078226647 @default.
- W2804717872 cites W2078699298 @default.
- W2804717872 cites W2080667228 @default.
- W2804717872 cites W2092411481 @default.
- W2804717872 cites W2094407932 @default.
- W2804717872 cites W2098437964 @default.
- W2804717872 cites W2106641477 @default.
- W2804717872 cites W2113911442 @default.
- W2804717872 cites W2115198211 @default.
- W2804717872 cites W2118942950 @default.
- W2804717872 cites W2123653059 @default.
- W2804717872 cites W2128475302 @default.
- W2804717872 cites W2129026591 @default.
- W2804717872 cites W2133415315 @default.
- W2804717872 cites W2134038068 @default.
- W2804717872 cites W2139818147 @default.
- W2804717872 cites W2142429733 @default.
- W2804717872 cites W2146412018 @default.
- W2804717872 cites W2152059298 @default.
- W2804717872 cites W2152718617 @default.
- W2804717872 cites W2168027290 @default.
- W2804717872 cites W2169457085 @default.
- W2804717872 cites W2186513281 @default.
- W2804717872 cites W2253900102 @default.
- W2804717872 cites W2293612652 @default.
- W2804717872 cites W2335534790 @default.
- W2804717872 cites W2463620236 @default.
- W2804717872 cites W2547783103 @default.
- W2804717872 cites W2797732082 @default.
- W2804717872 cites W4242530862 @default.
- W2804717872 cites W4295334631 @default.
- W2804717872 doi "https://doi.org/10.1101/328781" @default.
- W2804717872 hasPublicationYear "2018" @default.
- W2804717872 type Work @default.
- W2804717872 sameAs 2804717872 @default.
- W2804717872 citedByCount "0" @default.
- W2804717872 crossrefType "posted-content" @default.
- W2804717872 hasAuthorship W2804717872A5002348228 @default.
- W2804717872 hasAuthorship W2804717872A5008279566 @default.
- W2804717872 hasAuthorship W2804717872A5026261579 @default.
- W2804717872 hasAuthorship W2804717872A5050616644 @default.
- W2804717872 hasAuthorship W2804717872A5054005941 @default.
- W2804717872 hasAuthorship W2804717872A5055122406 @default.
- W2804717872 hasAuthorship W2804717872A5071188181 @default.
- W2804717872 hasAuthorship W2804717872A5072005666 @default.
- W2804717872 hasAuthorship W2804717872A5073318993 @default.
- W2804717872 hasBestOaLocation W28047178721 @default.
- W2804717872 hasConcept C104317684 @default.
- W2804717872 hasConcept C105702510 @default.
- W2804717872 hasConcept C136834591 @default.
- W2804717872 hasConcept C169760540 @default.
- W2804717872 hasConcept C171056886 @default.
- W2804717872 hasConcept C203014093 @default.
- W2804717872 hasConcept C2776878037 @default.
- W2804717872 hasConcept C2776914184 @default.
- W2804717872 hasConcept C2777594495 @default.
- W2804717872 hasConcept C2778334475 @default.
- W2804717872 hasConcept C2779830541 @default.
- W2804717872 hasConcept C2780775167 @default.
- W2804717872 hasConcept C2780884517 @default.
- W2804717872 hasConcept C28328180 @default.
- W2804717872 hasConcept C2909073510 @default.
- W2804717872 hasConcept C4746552 @default.
- W2804717872 hasConcept C529278444 @default.