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- W2804739147 abstract "Next-generation sequencing (NGS) enabled high-throughput analysis of genotype–phenotype relationships on human populations, ushering in a new era of genetics-informed drug development. The year 2017 was remarkable, with the first FDA-approved gene therapy for cancer (Kymriah™) and for inherited diseases (LUXTURNA™), the first multiplex NGS panel for companion diagnostics (MSK-IMPACT™) and the first drug targeting a genetic signature rather than a disease (Keytruda®). We envision that population-scale NGS with paired electronic health records (EHRs) will become a routine measure in the drug development process for the identification of novel drug targets, and that genetically stratified clinical trials could be widely adopted to improve power in precision-medicine-guided drug development." @default.
- W2804739147 created "2018-06-01" @default.
- W2804739147 creator A5057269030 @default.
- W2804739147 creator A5073531557 @default.
- W2804739147 date "2018-10-01" @default.
- W2804739147 modified "2023-10-07" @default.
- W2804739147 title "Next-generation sequencing in drug development: target identification and genetically stratified clinical trials" @default.
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- W2804739147 doi "https://doi.org/10.1016/j.drudis.2018.05.015" @default.
- W2804739147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29758342" @default.
- W2804739147 hasPublicationYear "2018" @default.