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- W2804759043 endingPage "1038" @default.
- W2804759043 startingPage "1021" @default.
- W2804759043 abstract "All the components of the classic renin–angiotensin system (RAS) have been identified in the brain. Today, the RAS is considered to be composed mainly of two axes: the pressor axis, represented by angiotensin (Ang) II/angiotensin-converting enzyme/AT1 receptors, and the depressor and protective one, represented by Ang-(1–7)/ angiotensin-converting enzyme 2/Mas receptors. Although the RAS exerts a pivotal role on electrolyte homeostasis and blood pressure regulation, their components are also implicated in higher brain functions, including cognition, memory, anxiety and depression, and several neurological disorders. Overactivity of the pressor axis of the RAS has been implicated in stroke and several brain disorders, such as cognitive impairment, dementia, and Alzheimer or Parkinson’s disease. The present review is focused on the role of the protective axis of the RAS in brain disorders beyond its effects on blood pressure regulation. Furthermore, the use of drugs targeting centrally RAS and its beneficial effects on brain disorders are also discussed." @default.
- W2804759043 created "2018-06-01" @default.
- W2804759043 creator A5008000437 @default.
- W2804759043 creator A5056940486 @default.
- W2804759043 creator A5080895720 @default.
- W2804759043 creator A5091131338 @default.
- W2804759043 date "2018-05-25" @default.
- W2804759043 modified "2023-10-09" @default.
- W2804759043 title "The depressor axis of the renin–angiotensin system and brain disorders: a translational approach" @default.
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