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• W2804759993 abstract "ABSTRACT The metabolic network of an organism includes the sum total of the biochemical reactions present. In microbes, this network has an impeccable ability to sense and respond to perturbations caused by internal or external stimuli. The metabolic potential (i.e., network structure) of an organism is often drawn from the genome sequence, based on the presence of enzymes deemed to indicate specific pathways. Escherichia coli and Salmonella enterica are members of the Enterobacteriaceae family of Gram-negative bacteria that share the majority of their metabolic components and regulatory machinery as the “core genome.” In S. enterica , the ability of the enamine intermediate 2-aminoacrylate (2AA) to inactivate a number of pyridoxal 5′-phosphate (PLP)-dependent enzymes has been established in vivo . In this study, 2AA metabolism and the consequences of its accumulation were investigated in E. coli . The data showed that despite the conservation of all relevant enzymes, S. enterica and E. coli differed in both the generation and detrimental consequences of 2AA. In total, these findings suggest that the structure of the metabolic network surrounding the generation and response to endogenous 2AA stress differs between S. enterica and E. coli . IMPORTANCE This work compared the metabolic networks surrounding the endogenous stressor 2-aminoacrylate in two closely related members of the Enterobacteriaceae . The data showed that despite the conservation of all relevant enzymes in this metabolic node, the two closely related organisms diverged in their metabolic network structures. This work highlights how a set of conserved components can generate distinct network architectures and how this can impact the physiology of an organism. This work defines a model to expand our understanding of the 2-aminoacrylate stress response and the differences in metabolic structures and cellular milieus between S. enterica and E. coli ." @default.
• W2804759993 created "2018-06-01" @default.
• W2804759993 creator A5036215581 @default.
• W2804759993 creator A5042656740 @default.
• W2804759993 date "2017-07-15" @default.
• W2804759993 modified "2023-09-27" @default.
• W2804759993 title "The Response to 2-Aminoacrylate Differs in Escherichia coli and Salmonella enterica, despite Shared Metabolic Components" @default.
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• W2804759993 doi "https://doi.org/10.1128/jb.00140-17" @default.
• W2804759993 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5494748" @default.
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