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- W2804771855 endingPage "e2005754" @default.
- W2804771855 startingPage "e2005754" @default.
- W2804771855 abstract "Phagocytes locate microorganisms via chemotaxis and then consume them using phagocytosis. Dictyostelium amoebas are stereotypical phagocytes that prey on diverse bacteria using both processes. However, as typical phagocytic receptors, such as complement receptors or Fcγ receptors, have not been found in Dictyostelium, it remains mysterious how these cells recognize bacteria. Here, we show that a single G-protein-coupled receptor (GPCR), folic acid receptor 1 (fAR1), simultaneously recognizes the chemoattractant folate and the phagocytic cue lipopolysaccharide (LPS), a major component of bacterial surfaces. Cells lacking fAR1 or its cognate G-proteins are defective in chemotaxis toward folate and phagocytosis of Klebsiella aerogenes. Computational simulations combined with experiments show that responses associated with chemotaxis can also promote engulfment of particles coated with chemoattractants. Finally, the extracellular Venus-Flytrap (VFT) domain of fAR1 acts as the binding site for both folate and LPS. Thus, fAR1 represents a new member of the pattern recognition receptors (PRRs) and mediates signaling from both bacterial surfaces and diffusible chemoattractants to reorganize actin for chemotaxis and phagocytosis." @default.
- W2804771855 created "2018-06-01" @default.
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- W2804771855 date "2018-05-25" @default.
- W2804771855 modified "2023-09-29" @default.
- W2804771855 title "A G-protein-coupled chemoattractant receptor recognizes lipopolysaccharide for bacterial phagocytosis" @default.
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- W2804771855 doi "https://doi.org/10.1371/journal.pbio.2005754" @default.
- W2804771855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5969738" @default.
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- W2804771855 hasPublicationYear "2018" @default.
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