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- W2804782304 abstract "Ultraviolet light is the dominant environmental oxidative skin stressor and a major skin aging factor. We studied which oxidized phospholipid (OxPL) mediators would be generated in primary human keratinocytes (KC) upon exposure to ultraviolet A light (UVA) and investigated the contribution of OxPL to UVA responses. Mass spectrometric analysis immediately or 24 h post UV stress revealed significant changes in abundance of 173 and 84 lipid species, respectively. We identified known and novel lipid species including known bioactive and also potentially reactive carbonyl containing species. We found indication for selective metabolism and degradation of selected reactive lipids. Exposure to both UVA and to in vitro UVA - oxidized phospholipids activated, on transcriptome and proteome level, NRF2/antioxidant response signaling, lipid metabolizing enzyme expression and unfolded protein response (UPR) signaling. We identified NUPR1 as an upstream regulator of UVA/OxPL transcriptional stress responses and found this protein to be expressed in the epidermis. Silencing of NUPR1 resulted in augmented expression of antioxidant and lipid detoxification genes and disturbed the cell cycle, making it a potential key factor in skin reactive oxygen species (ROS) responses intimately involved in aging and pathology." @default.
- W2804782304 created "2018-06-01" @default.
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- W2804782304 date "2019-01-01" @default.
- W2804782304 modified "2023-10-14" @default.
- W2804782304 title "A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids" @default.
- W2804782304 cites W1757834753 @default.
- W2804782304 cites W1912590178 @default.
- W2804782304 cites W1965680930 @default.
- W2804782304 cites W1970629217 @default.
- W2804782304 cites W1975669691 @default.
- W2804782304 cites W1980551026 @default.
- W2804782304 cites W1988918021 @default.
- W2804782304 cites W1993433559 @default.
- W2804782304 cites W1995246424 @default.
- W2804782304 cites W1997708774 @default.
- W2804782304 cites W2006260865 @default.
- W2804782304 cites W2008311655 @default.
- W2804782304 cites W2009519109 @default.
- W2804782304 cites W2019606302 @default.
- W2804782304 cites W2022279037 @default.
- W2804782304 cites W2023598683 @default.
- W2804782304 cites W2026550733 @default.
- W2804782304 cites W2030363360 @default.
- W2804782304 cites W2031737325 @default.
- W2804782304 cites W2033722815 @default.
- W2804782304 cites W2036646749 @default.
- W2804782304 cites W2037199116 @default.
- W2804782304 cites W2043419172 @default.
- W2804782304 cites W2053950470 @default.
- W2804782304 cites W2057371955 @default.
- W2804782304 cites W2062197104 @default.
- W2804782304 cites W2063116304 @default.
- W2804782304 cites W2067297015 @default.
- W2804782304 cites W2071740883 @default.
- W2804782304 cites W2074018752 @default.
- W2804782304 cites W2074662594 @default.
- W2804782304 cites W2075021009 @default.
- W2804782304 cites W2085975068 @default.
- W2804782304 cites W2087239201 @default.
- W2804782304 cites W2089200582 @default.
- W2804782304 cites W2092557247 @default.
- W2804782304 cites W2092655100 @default.
- W2804782304 cites W2093068595 @default.
- W2804782304 cites W2112799653 @default.
- W2804782304 cites W2116302596 @default.
- W2804782304 cites W2116987591 @default.
- W2804782304 cites W2119366144 @default.
- W2804782304 cites W2123794825 @default.
- W2804782304 cites W2123895133 @default.
- W2804782304 cites W2137511741 @default.
- W2804782304 cites W2139499629 @default.
- W2804782304 cites W2142308791 @default.
- W2804782304 cites W2143017568 @default.
- W2804782304 cites W2144411286 @default.
- W2804782304 cites W2145848160 @default.
- W2804782304 cites W2147929482 @default.
- W2804782304 cites W2148767345 @default.
- W2804782304 cites W2149640531 @default.
- W2804782304 cites W2153400793 @default.
- W2804782304 cites W2153819462 @default.
- W2804782304 cites W2158487294 @default.
- W2804782304 cites W2159027398 @default.
- W2804782304 cites W2161134291 @default.
- W2804782304 cites W2167760404 @default.
- W2804782304 cites W2170776626 @default.
- W2804782304 cites W2270369744 @default.
- W2804782304 cites W2313757542 @default.
- W2804782304 cites W2320106562 @default.
- W2804782304 cites W2412109671 @default.
- W2804782304 cites W2413082478 @default.
- W2804782304 cites W2425295107 @default.
- W2804782304 cites W2471458939 @default.
- W2804782304 cites W2506283615 @default.
- W2804782304 cites W2524832026 @default.
- W2804782304 cites W2530158439 @default.
- W2804782304 cites W2532180243 @default.
- W2804782304 cites W2544360569 @default.
- W2804782304 cites W2562237036 @default.
- W2804782304 cites W2562421673 @default.
- W2804782304 cites W2566908248 @default.
- W2804782304 cites W2577145272 @default.
- W2804782304 cites W2590472357 @default.