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- W2804784773 abstract "The BEAS-2B continuous cell line is an extensively used in vitro model for normal human bronchial epithelium. Inspection of the literature reveals that the culturing conditions used to maintain this cell line vary greatly among the different research groups that employ it. In this study, we showed that changes in the growth medium and/or the mixture used to promote attachment produced alterations in several growth characteristics (cell morphology, pattern of growth and adhesion to the substrate) of this cell line. On the contrary, doubling times remained unchanged. Considering that this cell line is recommended for the study of long-term processes, namely carcinogenesis, we have also examined the impact of extended passaging on its growth characteristics and genomic stability. Our study showed that culturing these cells over an extended period of time resulted in significant alterations in cell morphology, pattern of growth, adhesion to the substrate, doubling time and chromosomal complement. On the other hand, sensitivity to fetal bovine serum (FBS), an inducer of squamous differentiation, remained unchanged. Altogether, the phenotypic changes observed in our study might explain, at least partly, different study outcomes using this cell line that can be found in the literature." @default.
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- W2804784773 date "2018-05-01" @default.
- W2804784773 modified "2023-09-27" @default.
- W2804784773 title "Impact of the culturing conditions and culture age on the growth characteristics and genomic stability of BEAS-2B cells" @default.
- W2804784773 doi "https://doi.org/10.1016/j.freeradbiomed.2018.04.307" @default.
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