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- W2804802457 endingPage "338" @default.
- W2804802457 startingPage "315" @default.
- W2804802457 abstract "The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a large polypeptide of over 4000 amino acids with serine/threonine protein kinase activity that is enhanced in the presence of double stranded DNA and the Ku70/80 heterodimer. The discovery of this DNA activated protein kinase activity led to investigation of its role in DNA double-strand break repair and DNA-PKcs was shown to play important roles in repair of ionizing radiation-induced DNA double strand breaks and V(D)J recombination through the non-homologous end joining (NHEJ) pathway. However, recently, additional roles for DNA-PKcs in mitosis, transcription and cell migration have been suggested. Here, we review the structure, established and emerging roles of DNA-PKcs and its potential as a target for cancer therapy." @default.
- W2804802457 created "2018-06-01" @default.
- W2804802457 creator A5035453779 @default.
- W2804802457 creator A5036108302 @default.
- W2804802457 date "2018-01-01" @default.
- W2804802457 modified "2023-09-24" @default.
- W2804802457 title "Established and Emerging Roles of the DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs)" @default.
- W2804802457 cites W104404459 @default.
- W2804802457 cites W1181418255 @default.
- W2804802457 cites W1494965011 @default.
- W2804802457 cites W1499226315 @default.
- W2804802457 cites W1529783938 @default.
- W2804802457 cites W1540458755 @default.
- W2804802457 cites W1546557480 @default.
- W2804802457 cites W1566257366 @default.
- W2804802457 cites W1589684646 @default.
- W2804802457 cites W1601973031 @default.
- W2804802457 cites W1666093095 @default.
- W2804802457 cites W1767798659 @default.
- W2804802457 cites W1912902862 @default.
- W2804802457 cites W1959049775 @default.
- W2804802457 cites W1963613246 @default.
- W2804802457 cites W1964230664 @default.
- W2804802457 cites W1969173539 @default.
- W2804802457 cites W1969331397 @default.
- W2804802457 cites W1969393623 @default.
- W2804802457 cites W1970827792 @default.
- W2804802457 cites W1971204601 @default.
- W2804802457 cites W1972313386 @default.
- W2804802457 cites W1974010399 @default.
- W2804802457 cites W1974621964 @default.
- W2804802457 cites W1976336745 @default.
- W2804802457 cites W1977145510 @default.
- W2804802457 cites W1978518304 @default.
- W2804802457 cites W1978754000 @default.
- W2804802457 cites W1980251789 @default.
- W2804802457 cites W1980951231 @default.
- W2804802457 cites W1985564615 @default.
- W2804802457 cites W1986448084 @default.
- W2804802457 cites W1986830781 @default.
- W2804802457 cites W1987322786 @default.
- W2804802457 cites W1987577420 @default.
- W2804802457 cites W1989445129 @default.
- W2804802457 cites W1992860902 @default.
- W2804802457 cites W1994940147 @default.
- W2804802457 cites W1996131612 @default.
- W2804802457 cites W1999012527 @default.
- W2804802457 cites W1999940496 @default.
- W2804802457 cites W2000919464 @default.
- W2804802457 cites W2002420019 @default.
- W2804802457 cites W2004477375 @default.
- W2804802457 cites W2006552986 @default.
- W2804802457 cites W2007369689 @default.
- W2804802457 cites W2008415057 @default.
- W2804802457 cites W2011522975 @default.
- W2804802457 cites W2012425247 @default.
- W2804802457 cites W2013617428 @default.
- W2804802457 cites W2014593047 @default.
- W2804802457 cites W2019554117 @default.
- W2804802457 cites W2022529631 @default.
- W2804802457 cites W2022685241 @default.
- W2804802457 cites W2023324317 @default.
- W2804802457 cites W2023579322 @default.
- W2804802457 cites W2030205108 @default.
- W2804802457 cites W2030763718 @default.
- W2804802457 cites W2030955447 @default.
- W2804802457 cites W2031365072 @default.
- W2804802457 cites W2035892621 @default.
- W2804802457 cites W2036029612 @default.
- W2804802457 cites W2037819392 @default.
- W2804802457 cites W2042645510 @default.
- W2804802457 cites W2042663808 @default.
- W2804802457 cites W2044536320 @default.
- W2804802457 cites W2044874191 @default.
- W2804802457 cites W2047619014 @default.
- W2804802457 cites W2048916500 @default.
- W2804802457 cites W2050880187 @default.
- W2804802457 cites W2051550009 @default.
- W2804802457 cites W2054373762 @default.
- W2804802457 cites W2055627594 @default.
- W2804802457 cites W2057001689 @default.
- W2804802457 cites W2057562851 @default.
- W2804802457 cites W2058332866 @default.
- W2804802457 cites W2060002498 @default.
- W2804802457 cites W2061060103 @default.
- W2804802457 cites W2063691867 @default.
- W2804802457 cites W2063767041 @default.
- W2804802457 cites W2064631075 @default.
- W2804802457 cites W2069964111 @default.
- W2804802457 cites W2072209077 @default.
- W2804802457 cites W2072957347 @default.
- W2804802457 cites W2076143694 @default.
- W2804802457 cites W2076910970 @default.
- W2804802457 cites W2077727614 @default.
- W2804802457 cites W2077830374 @default.
- W2804802457 cites W2079472423 @default.
- W2804802457 cites W2081183767 @default.
- W2804802457 cites W2086005521 @default.