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• W2804814625 abstract "The good bioactivity of hydroxyapatite (HA) makes it become a popular biomaterial, and so, the synthesis of HA has attracted much attention. However, a simple method to prepare well-dispersive and ultrafine HA nanoparticles (NPs) still needs to be explored. Here, needle-like hybrid HA NPs were synthesized in the presence of alginate (ALG) and the mechanism of ALG regulation on forming HA/ALG hybrid NPs was investigated. The size and crystallinity of HA/ALG NPs could be controlled simply by varying the amount of ALG. With a higher concentration of ALG, the size of HA/ALG NPs reduced and their dispersity was further improved. The assembly with ca. 3-6 nm thick nanoneedles was discernible in HA/ALG NPs. The results collected by Ca2+ concentration, pH, and conductometric measurements further provided the supportive data for ALG inhibition of calcium phosphate compound formation and thus modulation of HA crystallization. In addition, the good biocompatibility of synthesized HA/ALG NPs was indicated from the results of CCK-8 assays and CLSM observations after cultured with L929 cells. The needle-like HA NPs are promising for varied biomedical purposes, and their potential application as drug carriers would be further studied." @default.
• W2804814625 created "2018-06-01" @default.
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• W2804814625 date "2018-05-17" @default.
• W2804814625 modified "2023-10-14" @default.
• W2804814625 title "Alginate-Mediated Mineralization for Ultrafine Hydroxyapatite Hybrid Nanoparticles" @default.
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• W2804814625 doi "https://doi.org/10.1021/acs.langmuir.8b00151" @default.
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• W2804814625 hasPublicationYear "2018" @default.
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