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- W2804844247 abstract "ObjectiveTo assess the diagnostic value of 18F-FDG PET/CT on mediastinal lymph node(MLN) metastasis in non-small cell lung cancer(NSCLC) by Meta analysis.MethodsPublications on MLN staging of NSCLC by PET/CT published from 1990 to 2016 were filtered and assessed according to the criteria from Wanfang, China National Knowledge Infrastructure, Vip database, PubMed, Embase, Cochrane Library database. Receiver operating characteristic curve analysis was applied and senstivity, specificity, positive likelihood ratio (PLR) , negative likelihood ratio (NLR) , diagnostic odds ratio (DOR) were calculated. The threshold effect analysis uses the area under the calculated curve. Subgroup analysis adopted t test.ResultsTwenty-two relevant literatures were enrolled (including 2543 patients) . Meta analysis showed that the pooled senstivity, specificity, PLR, NLR and DOR were 0.66 (0.62-0.69) , 0.82 (0.80-0.84) , 3.60 (2.82-4.58) , 0.45 (0.37-0.54) , 9.12 (6.15-13.52) , respectively. Area under curve was 0.826. The results of subgroup analysis suggested that there was a statistically significant difference between the history of tuberculosis and no history of tuberculosis, and pulmonary tuberculosis was one important factor which influenced the PET/CT diagnosis of MLN metastasis in NSCLC patients.ConclusionPET/CT has a high accuracy for the MLN staging in NSCLC patients.Key words: Carcinoma, non-small-cell lung; Lymph node metastasis; Positron-emission tomography; Tomography, X-ray computed; Fluorodeoxyglucose F18; Meta-analysis" @default.
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- W2804844247 date "2018-01-25" @default.
- W2804844247 modified "2023-10-18" @default.
- W2804844247 title "Diagnostic value of 18F-FDG PET/CT in the diagnosis of mediastinal lymph node metastasis in non-small cell lung cancer: a Meta-analysis" @default.
- W2804844247 doi "https://doi.org/10.3760/cma.j.issn.1673-4114.2018.01.010" @default.
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