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• W2804876543 abstract "Purpose . This study aimed to investigate the possible effects and underlying mechanisms of Kangzhi syrup on ovalbumin- (OVA-) induced cough variant asthma (CVA) in guinea pigs. Methods . All 48 guinea pigs were randomly assigned to four experimental groups: normal, OVA model with or without Kangzhi syrup (OVA and OVA + KZ), and OVA with Dexamethasone (OVA + DM). After sensitizing the guinea pigs, a cough challenge was performed by the inhalation of capsaicin. The antitussive effect, inflammatory cells, cytokines in bronchoalveolar lavage fluid (BALF) and lung tissue, and morphological changes were examined. Results . Compared with model group, Kangzhi syrup effectively exerted an antitussive effect (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.0</mml:mn><mml:mn fontstyle=italic>001</mml:mn></mml:math>) and reduced the pneumonic anaphylacticitis by inhibiting the infiltration of total inflammatory cells (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.0</mml:mn><mml:mn fontstyle=italic>001</mml:mn></mml:math>) and reducing the percentage of eosinophil in BALF (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.0</mml:mn><mml:mn fontstyle=italic>001</mml:mn></mml:math>). Moreover, evidence from morphological studies also demonstrated that Kangzhi syrup inhibited the infiltration of inflammatory cells and ameliorated the structure changes. NF- κ B and TGF- β 1 expression were attenuated in the OVA + KZ group versus the OVA group (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.0</mml:mn><mml:mn fontstyle=italic>001</mml:mn></mml:math>). Additionally, a semiquantitative analysis of TGF- β 1 expression also demonstrated that the Kangzhi syrup attenuated this profibrogenic growth factor (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.0</mml:mn><mml:mn fontstyle=italic>01</mml:mn></mml:math>). Conclusions . The results demonstrated that Kangzhi syrup exerted a considerable antitussive effect in CVA animal model, which depended on its marked impact on the anti-anaphylactic inflammation. Additionally, it could ameliorate the airway remodeling by inhibiting NF- κ B and TGF- β 1 signal pathway." @default.
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• W2804876543 date "2018-01-01" @default.
• W2804876543 modified "2023-10-15" @default.
• W2804876543 title "Therapeutic Effects of Kangzhi Syrup in a Guinea Pig Model of Ovalbumin-Induced Cough Variant Asthma" @default.
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• W2804876543 doi "https://doi.org/10.1155/2018/5867835" @default.
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