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- W2804906312 abstract "Abstract Major depressive disorder (MDD) has been conceived as a neuroprogressive illness in a subset of patients and is associated with progressive structural and functional brain abnormalities, due to reduced neurogenesis, dysfunction in neural plasticity, and increased apoptosis. Inflammatory cytokines and cell-mediated immunity may play a role in these abnormalities by activating microglial cells or modulating several pathways involved in neural physiology and homeostasis. Nevertheless, increasing evidence points out that depression is associated with peripheral immune activation in only a subset of patients. Moreover, the observations that immune activation can be involved in mood and cognitive symptoms across several psychiatric, neurological, and medical diseases warrant the need for a transdiagnostic dimensional approach, which is addressed by the Research Domain Criteria framework. Drugs with antiinflammatory activity may be efficacious for the treatment of depression in patients with elevated markers of peripheral inflammation and could also provide domain-specific treatment for specific symptoms. Further translational research is needed to identify new drug targets that may provide a pathway toward precision psychiatry." @default.
- W2804906312 created "2018-06-01" @default.
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- W2804906312 date "2018-01-01" @default.
- W2804906312 modified "2023-10-17" @default.
- W2804906312 title "Pathways Driving Neuroprogression in Depression: The Role of Immune Activation" @default.
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