FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804919005> ?p ?o ?g. }

• W2804919005 endingPage "568" @default.
• W2804919005 startingPage "559" @default.
• W2804919005 abstract "Recent studies have reported dysregulated expression of matrix metalloproteinases (MMPs), especially MMP-2, MMP-9, tissue inhibitor of metalloproteinase-1, -2 (TIMP-1, TIMP-2), and extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in activated macrophages of patients with inflammatory diseases. Therefore, MMP-2, MMP-9, and their regulators may represent a new target for treatment of inflammatory diseases. Probiotics, which are comprised of lactic acid bacteria, have the potential to modulate inflammatory responses. In this experimental study, we investigated the anti-inflammatory effects of cell-free supernatants (CFS) from Lactobacillus acidophilus (L. acidophilus) and L. rhamnosus GG (LGG) in phorbol myristate acetate (PMA)-differentiated THP-1 cells.In this experimental study, PMA-differentiated THP-1 cells were treated with CFS from L. acidophilus, LGG and uninoculated bacterial growth media (as a control). The expression of MMP-2, MMP-9, TIMP-1, and TIMP-2 mRNAs were determined using real-time quantitative reverse transcription polymerase chain reaction (RTPCR). The levels of cellular surface expression of CD147 were assessed by flow cytometry, and the gelatinolytic activity of MMP-2 and MMP-9 were determined by zymography.Our results showed that CFS from both L. acidophilus and LGG significantly inhibited the gene expression of MMP-9 (P=0.0011 and P=0.0005, respectively), increased the expression of TIMP-1 (P<0.0001), decreased the cell surface expression of CD147 (P=0.0307 and P=0.0054, respectively), and inhibited the gelatinolytic activity of MMP-9 (P=0.0003 and P<0.0001, respectively) in PMA-differentiated THP-1 cells. Although, MMP-2 expression and activity and TIMP-2 expression remained unchanged.Our results indicate that CFS from L. acidophilus and LGG possess anti-inflammatory properties and can modulate the inflammatory response." @default.
• W2804919005 created "2018-06-01" @default.
• W2804919005 creator A5005262843 @default.
• W2804919005 creator A5040312012 @default.
• W2804919005 creator A5052050053 @default.
• W2804919005 creator A5064229359 @default.
• W2804919005 creator A5084722942 @default.
• W2804919005 creator A5089563433 @default.
• W2804919005 date "2018-01-01" @default.
• W2804919005 modified "2023-10-18" @default.
• W2804919005 title "Dual Effects of Cell Free Supernatants from Lactobacillus acidophilus and Lactobacillus rhamnosus GG in Regulation of MMP-9 by Up-Regulating TIMP-1 and Down-Regulating CD147 in PMADifferentiated THP-1 Cells." @default.
• W2804919005 cites W102715504 @default.
• W2804919005 cites W1519720742 @default.
• W2804919005 cites W1569650715 @default.
• W2804919005 cites W1601926208 @default.
• W2804919005 cites W1757737075 @default.
• W2804919005 cites W1926532709 @default.
• W2804919005 cites W1939804949 @default.
• W2804919005 cites W1941532421 @default.
• W2804919005 cites W1951810527 @default.
• W2804919005 cites W1978714754 @default.
• W2804919005 cites W1988821718 @default.
• W2804919005 cites W1997826997 @default.
• W2804919005 cites W1998515823 @default.
• W2804919005 cites W2007855732 @default.
• W2804919005 cites W2009155188 @default.
• W2804919005 cites W2009328648 @default.
• W2804919005 cites W2017429999 @default.
• W2804919005 cites W2017586800 @default.
• W2804919005 cites W2028012069 @default.
• W2804919005 cites W2028207211 @default.
• W2804919005 cites W2028288720 @default.
• W2804919005 cites W2037786647 @default.
• W2804919005 cites W2042426975 @default.
• W2804919005 cites W2046658516 @default.
• W2804919005 cites W2047015493 @default.
• W2804919005 cites W2052554412 @default.
• W2804919005 cites W2056782822 @default.
• W2804919005 cites W2060076992 @default.
• W2804919005 cites W2061626688 @default.
• W2804919005 cites W2069004304 @default.
• W2804919005 cites W2071065837 @default.
• W2804919005 cites W2073964648 @default.
• W2804919005 cites W2076496958 @default.
• W2804919005 cites W2088821061 @default.
• W2804919005 cites W2113437765 @default.
• W2804919005 cites W2116786392 @default.
• W2804919005 cites W2117507430 @default.
• W2804919005 cites W2121222441 @default.
• W2804919005 cites W2123578869 @default.
• W2804919005 cites W2139759128 @default.
• W2804919005 cites W2140703378 @default.
• W2804919005 cites W2144587414 @default.
• W2804919005 cites W2149952321 @default.
• W2804919005 cites W2152003312 @default.
• W2804919005 cites W2155311002 @default.
• W2804919005 cites W2164758161 @default.
• W2804919005 cites W2166742894 @default.
• W2804919005 cites W2169829611 @default.
• W2804919005 cites W2171742795 @default.
• W2804919005 cites W2314504499 @default.
• W2804919005 cites W40731526 @default.
• W2804919005 doi "https://doi.org/10.22074/cellj.2018.4447" @default.
• W2804919005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5672094" @default.
• W2804919005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29105390" @default.
• W2804919005 hasPublicationYear "2018" @default.
• W2804919005 type Work @default.
• W2804919005 sameAs 2804919005 @default.
• W2804919005 citedByCount "16" @default.
• W2804919005 countsByYear W28049190052017 @default.
• W2804919005 countsByYear W28049190052018 @default.
• W2804919005 countsByYear W28049190052019 @default.
• W2804919005 countsByYear W28049190052020 @default.
• W2804919005 countsByYear W28049190052021 @default.
• W2804919005 countsByYear W28049190052022 @default.
• W2804919005 countsByYear W28049190052023 @default.
• W2804919005 crossrefType "journal-article" @default.
• W2804919005 hasAuthorship W2804919005A5005262843 @default.
• W2804919005 hasAuthorship W2804919005A5040312012 @default.
• W2804919005 hasAuthorship W2804919005A5052050053 @default.
• W2804919005 hasAuthorship W2804919005A5064229359 @default.
• W2804919005 hasAuthorship W2804919005A5084722942 @default.
• W2804919005 hasAuthorship W2804919005A5089563433 @default.
• W2804919005 hasConcept C104317684 @default.
• W2804919005 hasConcept C109523444 @default.
• W2804919005 hasConcept C1491633281 @default.
• W2804919005 hasConcept C150194340 @default.
• W2804919005 hasConcept C153911025 @default.
• W2804919005 hasConcept C177430391 @default.
• W2804919005 hasConcept C203014093 @default.
• W2804919005 hasConcept C204258353 @default.
• W2804919005 hasConcept C2776651480 @default.
• W2804919005 hasConcept C2776914184 @default.
• W2804919005 hasConcept C2777221637 @default.
• W2804919005 hasConcept C2780255968 @default.
• W2804919005 hasConcept C4692481 @default.
• W2804919005 hasConcept C523546767 @default.
• W2804919005 hasConcept C54355233 @default.

• next