Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804927712> ?p ?o ?g. }
- W2804927712 endingPage "703" @default.
- W2804927712 startingPage "689" @default.
- W2804927712 abstract "Context: Accidental exposure to life-threatening radiation in a nuclear event is a major concern; there is an enormous need for identifying biomarkers for radiation biodosimetry to triage populations and treat critically exposed individuals.Objective: To identify dose-differentiating miRNA signatures from whole blood samples of whole body irradiated mice.Methods: Mice were whole body irradiated with X-rays (2 Gy–15 Gy); blood was collected at various time-points post-exposure; total RNA was isolated; miRNA microarrays were performed; miRNAs differentially expressed in irradiated vs. unirradiated controls were identified; feature extraction and classification models were applied to predict dose-differentiating miRNA signature.Results: We observed a time and dose responsive alteration in the expression levels of miRNAs. Maximum number of miRNAs were altered at 24-h and 48-h time-points post-irradiation. A 23-miRNA signature was identified using feature selection algorithms and classifier models. An inverse correlation in the expression level changes of miR-17 members, and their targets were observed in whole body irradiated mice and non-human primates.Conclusion: Whole blood-based miRNA expression signatures might be used for predicting radiation exposures in a mass casualty nuclear incident." @default.
- W2804927712 created "2018-06-01" @default.
- W2804927712 creator A5010437696 @default.
- W2804927712 creator A5038837438 @default.
- W2804927712 creator A5052554629 @default.
- W2804927712 creator A5059202876 @default.
- W2804927712 creator A5060829624 @default.
- W2804927712 creator A5072154003 @default.
- W2804927712 creator A5072871907 @default.
- W2804927712 creator A5083432144 @default.
- W2804927712 creator A5085871120 @default.
- W2804927712 creator A5086403145 @default.
- W2804927712 date "2018-06-19" @default.
- W2804927712 modified "2023-10-18" @default.
- W2804927712 title "Microarray analysis of miRNA expression profiles following whole body irradiation in a mouse model" @default.
- W2804927712 cites W1595524810 @default.
- W2804927712 cites W161540545 @default.
- W2804927712 cites W1964351261 @default.
- W2804927712 cites W1964591535 @default.
- W2804927712 cites W1966466754 @default.
- W2804927712 cites W1966626540 @default.
- W2804927712 cites W1970452772 @default.
- W2804927712 cites W1971615688 @default.
- W2804927712 cites W1977135648 @default.
- W2804927712 cites W1977990120 @default.
- W2804927712 cites W1986761262 @default.
- W2804927712 cites W1993642265 @default.
- W2804927712 cites W1993952744 @default.
- W2804927712 cites W2006247279 @default.
- W2804927712 cites W2015284016 @default.
- W2804927712 cites W2017426710 @default.
- W2804927712 cites W2024013032 @default.
- W2804927712 cites W2024530190 @default.
- W2804927712 cites W2027744584 @default.
- W2804927712 cites W2043704189 @default.
- W2804927712 cites W2046090531 @default.
- W2804927712 cites W2050434028 @default.
- W2804927712 cites W2058176612 @default.
- W2804927712 cites W2064921823 @default.
- W2804927712 cites W2066522391 @default.
- W2804927712 cites W2066649300 @default.
- W2804927712 cites W2070412447 @default.
- W2804927712 cites W2070571588 @default.
- W2804927712 cites W2077327925 @default.
- W2804927712 cites W2094291221 @default.
- W2804927712 cites W2107386301 @default.
- W2804927712 cites W2112192177 @default.
- W2804927712 cites W2120806715 @default.
- W2804927712 cites W2121787561 @default.
- W2804927712 cites W2127472615 @default.
- W2804927712 cites W2129129308 @default.
- W2804927712 cites W2143420653 @default.
- W2804927712 cites W2145918100 @default.
- W2804927712 cites W2153841325 @default.
- W2804927712 cites W2157449473 @default.
- W2804927712 cites W2259938310 @default.
- W2804927712 cites W2318998587 @default.
- W2804927712 cites W2343423203 @default.
- W2804927712 cites W2500197682 @default.
- W2804927712 cites W2528070793 @default.
- W2804927712 cites W2570544313 @default.
- W2804927712 cites W2584102880 @default.
- W2804927712 cites W2588839509 @default.
- W2804927712 cites W2626072141 @default.
- W2804927712 cites W2783613783 @default.
- W2804927712 cites W2786189816 @default.
- W2804927712 cites W4239510810 @default.
- W2804927712 cites W4243930828 @default.
- W2804927712 doi "https://doi.org/10.1080/1354750x.2018.1479771" @default.
- W2804927712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6982201" @default.
- W2804927712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29799276" @default.
- W2804927712 hasPublicationYear "2018" @default.
- W2804927712 type Work @default.
- W2804927712 sameAs 2804927712 @default.
- W2804927712 citedByCount "25" @default.
- W2804927712 countsByYear W28049277122019 @default.
- W2804927712 countsByYear W28049277122020 @default.
- W2804927712 countsByYear W28049277122021 @default.
- W2804927712 countsByYear W28049277122022 @default.
- W2804927712 countsByYear W28049277122023 @default.
- W2804927712 crossrefType "journal-article" @default.
- W2804927712 hasAuthorship W2804927712A5010437696 @default.
- W2804927712 hasAuthorship W2804927712A5038837438 @default.
- W2804927712 hasAuthorship W2804927712A5052554629 @default.
- W2804927712 hasAuthorship W2804927712A5059202876 @default.
- W2804927712 hasAuthorship W2804927712A5060829624 @default.
- W2804927712 hasAuthorship W2804927712A5072154003 @default.
- W2804927712 hasAuthorship W2804927712A5072871907 @default.
- W2804927712 hasAuthorship W2804927712A5083432144 @default.
- W2804927712 hasAuthorship W2804927712A5085871120 @default.
- W2804927712 hasAuthorship W2804927712A5086403145 @default.
- W2804927712 hasBestOaLocation W28049277122 @default.
- W2804927712 hasConcept C104317684 @default.
- W2804927712 hasConcept C111337013 @default.
- W2804927712 hasConcept C121332964 @default.
- W2804927712 hasConcept C142724271 @default.
- W2804927712 hasConcept C145059251 @default.
- W2804927712 hasConcept C150194340 @default.