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- W2804940243 abstract "Ruthenium polypyridyl complexes are of interest for their possible applications as cellular probes, in anticancer therapeutics and, most recently, for their antibacterial properties. For many years there was no crystallographic evidence showing how any of these complexes bound to duplex or higher-order DNA, but since 2011 a series of structural studies have shown aspects of sequence, enantiomeric, substituent and structural specificity. The principal binding mode to duplex DNA of complexes typified by [Ru(phen)2dppz]2+ (where dppz=dipyridophenazene) is by angled (canted) intercalation from the minor groove, with a distinct symmetric binding mode so far only known for lambda enantiomers at the TA/TA steps. Kinking (semi-intercalation) has also been characterised, so far only at CC/GG steps, e.g. for phen ligands within these complexes. Delta enantiomers are capable of mismatch recognition, so far structurally characterised for the A–A mismatch. This binding mode, insertion, is characterised by the flipping out of the adenine, with the base stacking on the ancillary ligand of the complex. For binding to higher-order DNA, sequences with loops, such as the unimolecular G-quadruplex, have so far resisted attempts at crystallisation, although an NMR structure of a diruthenium complex has been reported." @default.
- W2804940243 created "2018-06-01" @default.
- W2804940243 creator A5028181385 @default.
- W2804940243 creator A5069379002 @default.
- W2804940243 date "2018-03-12" @default.
- W2804940243 modified "2023-09-27" @default.
- W2804940243 title "Structural Studies of DNA-binding Metal Complexes of Therapeutic Importance" @default.
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- W2804940243 doi "https://doi.org/10.1039/9781788012928-00198" @default.
- W2804940243 hasPublicationYear "2018" @default.
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