Matches in SemOpenAlex for { <https://semopenalex.org/work/W2804967882> ?p ?o ?g. }
- W2804967882 abstract "γδ T cell-based immunotherapy for osteosarcoma (OS) has shown limited success thus far. DNA-demethylating agents not only induce tumor cell death but also have an immunomodulatory function. In this study, we have assessed the potential benefit of combining decitabine (DAC, a DNA demethylation drug) and γδ T cells for OS immunotherapy. DAC increased the expression of natural killer group 2D (NKG2D) ligands (NKG2DLs), including major histocompatibility complex class I-related chains B (MICB) and UL16-binding protein 1 (ULBP1), on the OS cell surface, making the cells more sensitive to recognition and destruction by cytotoxic γδ T cells. The upregulation of MICB and ULBP1 was due to promoter DNA demethylation. Importantly, the killing of OS cells by γδ T cells was partially reversed by blocking the NKG2D receptor, suggesting that the γδ T cell-mediated cytolysis of DAC-pretreated OS cells was mainly dependent on the NKG2D-NKG2DL axis. The in vivo results were consistent with the in vitro results. In summary, DAC could upregulate MICB and ULBP1 expression in OS cells, and combination treatment involving γδ T cell immunotherapy and DAC could be used to enhance the cytotoxic killing of OS cells by γδ T cells." @default.
- W2804967882 created "2018-06-01" @default.
- W2804967882 creator A5001228035 @default.
- W2804967882 creator A5007759566 @default.
- W2804967882 creator A5027377718 @default.
- W2804967882 creator A5037163615 @default.
- W2804967882 creator A5043933067 @default.
- W2804967882 creator A5052335250 @default.
- W2804967882 creator A5058391979 @default.
- W2804967882 creator A5071412917 @default.
- W2804967882 creator A5072317258 @default.
- W2804967882 creator A5076960605 @default.
- W2804967882 creator A5087185685 @default.
- W2804967882 date "2018-06-01" @default.
- W2804967882 modified "2023-10-11" @default.
- W2804967882 title "Decitabine Enhances Vγ9Vδ2 T Cell-Mediated Cytotoxic Effects on Osteosarcoma Cells via the NKG2DL–NKG2D Axis" @default.
- W2804967882 cites W1492374155 @default.
- W2804967882 cites W1518200090 @default.
- W2804967882 cites W1535243328 @default.
- W2804967882 cites W1854886860 @default.
- W2804967882 cites W1897399348 @default.
- W2804967882 cites W1907053720 @default.
- W2804967882 cites W1930633395 @default.
- W2804967882 cites W1970440039 @default.
- W2804967882 cites W1972120590 @default.
- W2804967882 cites W1972245883 @default.
- W2804967882 cites W1983058138 @default.
- W2804967882 cites W1983973479 @default.
- W2804967882 cites W1985328622 @default.
- W2804967882 cites W2000217892 @default.
- W2804967882 cites W2007996777 @default.
- W2804967882 cites W2017288179 @default.
- W2804967882 cites W2022859267 @default.
- W2804967882 cites W2037128064 @default.
- W2804967882 cites W2043756084 @default.
- W2804967882 cites W2076080909 @default.
- W2804967882 cites W2089801128 @default.
- W2804967882 cites W2093282432 @default.
- W2804967882 cites W2093914368 @default.
- W2804967882 cites W2109077280 @default.
- W2804967882 cites W2123745849 @default.
- W2804967882 cites W2125894767 @default.
- W2804967882 cites W2139619092 @default.
- W2804967882 cites W2141911566 @default.
- W2804967882 cites W2170263258 @default.
- W2804967882 cites W2171068988 @default.
- W2804967882 cites W2304674697 @default.
- W2804967882 cites W2343744278 @default.
- W2804967882 cites W2358704133 @default.
- W2804967882 cites W2411032707 @default.
- W2804967882 cites W2417767096 @default.
- W2804967882 cites W2519623594 @default.
- W2804967882 cites W2569435104 @default.
- W2804967882 cites W2586733270 @default.
- W2804967882 cites W2610204461 @default.
- W2804967882 cites W2735288958 @default.
- W2804967882 cites W2736197951 @default.
- W2804967882 cites W2749528955 @default.
- W2804967882 cites W2751784325 @default.
- W2804967882 cites W2752072744 @default.
- W2804967882 cites W2758263899 @default.
- W2804967882 cites W2775185528 @default.
- W2804967882 cites W2789555108 @default.
- W2804967882 cites W2792530328 @default.
- W2804967882 cites W2794124550 @default.
- W2804967882 cites W571557416 @default.
- W2804967882 doi "https://doi.org/10.3389/fimmu.2018.01239" @default.
- W2804967882 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5992281" @default.
- W2804967882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29910819" @default.
- W2804967882 hasPublicationYear "2018" @default.
- W2804967882 type Work @default.
- W2804967882 sameAs 2804967882 @default.
- W2804967882 citedByCount "26" @default.
- W2804967882 countsByYear W28049678822019 @default.
- W2804967882 countsByYear W28049678822020 @default.
- W2804967882 countsByYear W28049678822021 @default.
- W2804967882 countsByYear W28049678822022 @default.
- W2804967882 countsByYear W28049678822023 @default.
- W2804967882 crossrefType "journal-article" @default.
- W2804967882 hasAuthorship W2804967882A5001228035 @default.
- W2804967882 hasAuthorship W2804967882A5007759566 @default.
- W2804967882 hasAuthorship W2804967882A5027377718 @default.
- W2804967882 hasAuthorship W2804967882A5037163615 @default.
- W2804967882 hasAuthorship W2804967882A5043933067 @default.
- W2804967882 hasAuthorship W2804967882A5052335250 @default.
- W2804967882 hasAuthorship W2804967882A5058391979 @default.
- W2804967882 hasAuthorship W2804967882A5071412917 @default.
- W2804967882 hasAuthorship W2804967882A5072317258 @default.
- W2804967882 hasAuthorship W2804967882A5076960605 @default.
- W2804967882 hasAuthorship W2804967882A5087185685 @default.
- W2804967882 hasBestOaLocation W28049678821 @default.
- W2804967882 hasConcept C104317684 @default.
- W2804967882 hasConcept C109316439 @default.
- W2804967882 hasConcept C150194340 @default.
- W2804967882 hasConcept C153911025 @default.
- W2804967882 hasConcept C154317977 @default.
- W2804967882 hasConcept C185592680 @default.
- W2804967882 hasConcept C190727270 @default.
- W2804967882 hasConcept C202751555 @default.
- W2804967882 hasConcept C203014093 @default.