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• W2804981625 abstract "The present research investigates the size effect of Deferasirox, “4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1yl]-benzoicacid”, to reduce lead(II) poisoning in rat bodies. The lead(II) ions as PbCl2 was given orally to the rats in 40 mg/kg dose for 100 days. Deferasirox in nano scale was prepare d by sonochemistry method. The effects of initial substance (0.025, 0.05 and 0.1 g) and reaction time (15, 30 and 45 min) on deferasirox size were investigated. Chemotherapy by deferasirox in two scales, nano (16 nm) and bulk (6 μm), was done during 15 days. The lead(II) concentration in various tissues such as heart, liver, spleen and kidneys was determined by graphite furnace atomic absorption spectroscopy (GFAAS). The results show by decreasing in deferasirox particle size; more lead(II) amount were removed from rat’s organs." @default.
• W2804981625 created "2018-06-01" @default.
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• W2804981625 date "2018-05-15" @default.
• W2804981625 modified "2023-10-17" @default.
• W2804981625 title "Chelation therapy: Assessing the impact of deferasirox size on lead(II) release from biological systems" @default.
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• W2804981625 doi "https://doi.org/10.3233/mgc-180260" @default.
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