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• W2805038596 startingPage "290" @default.
• W2805038596 abstract "Atherosclerotic cardiovascular disease (ASCVD) is the number one cause of morbidity and mortality worldwide. Low-density lipoprotein cholesterol (LDL-C) has been implicated as one of the major risk factors causing ASCVD based on multiple hierarchical levels of evidence. The advent of powerful LDL-C lowering therapies, such as the proprotein convertase subtilisin/kexin type 9 inhibitor, have raised the question of how low to target LDL-C and whether there are any adverse safety events associated with a very low LDL-C level. The present review summarizes the available evidence and concludes that even a very low LDL-C is associated with cardiovascular benefit, although the magnitude of benefit depends on baseline ASCVD risk and the absolute change in LDL-C with pharmacologic therapy. The safety data in patients treated for very low LDL-C is reassuring, although it is inconsistent and requires longer term follow-up." @default.
• W2805038596 created "2018-06-13" @default.
• W2805038596 creator A5040577415 @default.
• W2805038596 creator A5060401094 @default.
• W2805038596 date "2018-08-01" @default.
• W2805038596 modified "2023-09-27" @default.
• W2805038596 title "Lowering LDL-Cholesterol and CV Benefits: Is There a Limit to How Low LDL-C Needs to be for Optimal Health Benefits?" @default.
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• W2805038596 doi "https://doi.org/10.1002/cpt.1133" @default.
• W2805038596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29882959" @default.
• W2805038596 hasPublicationYear "2018" @default.
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