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- W2805087145 abstract "T cell response plays an essential role in the host resistance to infection by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. This infection is often associated with multiple manifestations of T cell dysfunction, both during the acute and the chronic phases of disease. Additionally, the normal development of T cells is affected. As seen in animal models of Chagas disease, there is a strong thymic atrophy due to massive death of CD4+CD8+ double positive cells by apoptosis and an abnormal escape of immature and potentially autoreactive thymocytes from the organ. Furthermore, an increase in the release of corticosterone triggered by T. cruzi-driven systemic inflammation is strongly associated with the alterations seen in the thymus of infected animals. Moreover, changes in the levels of other hormones, including growth hormone, prolactin and testosterone are also able to contribute to the disruption of thymic homeostasis secondary to T. cruzi infection. In this review, discuss the role of hormonal circuits involved in the normal T cell development and trafficking, as well as their role on the thymic alterations likely related to the peripheral T cell disturbances largely reported in both chagasic patients and animal models of Chagas disease." @default.
- W2805087145 created "2018-06-13" @default.
- W2805087145 creator A5024312874 @default.
- W2805087145 creator A5063166816 @default.
- W2805087145 creator A5065159433 @default.
- W2805087145 creator A5065606337 @default.
- W2805087145 creator A5079130946 @default.
- W2805087145 date "2018-06-14" @default.
- W2805087145 modified "2023-10-06" @default.
- W2805087145 title "Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions" @default.
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