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• W2805107974 abstract "Advances in microfabrication technology andminiaturized analysis have led to the development of lab-on-a-chip(LOC) systems, which enables integration of multiple complexfunctions on a single device. With the reduction in size to themicrometer or nanometer scale, LOC devices to minimize consumptionof reagents, increase automation, and reduce manufacturing costs.Electrochemical and optical detection are popular techniques thatare compatible with LOC devices for chemical and biochemicalanalysis. Scalability of electrochemical and optical detectionschemes to smaller dimension enables the development of portablesensors with low background and enhanced sensitivity based on LOCdevices. This work demonstrates the design andfabrication of several specific LOC devices for differentapplications by integrating electrochemical and optical detection.An electrochemical reactor was developed for insitu generation and quantitative monitoring of oxygenwithin nanofluidic systems. In this device, an embedded microbandelectrode was employed for reagent generation, and fluorescein, apH-sensitive dye, was used as a reporter for monitoring thespatiotemporal distribution of generated O2 based on theco-produced H+. Importantly, the optical and electrochemicalmeasurements were in quantitative agreement on total generation,whereas the fluorescence images allowed spatial/temporal maps of O2to be generated. In the second application, bipolar electrode(BPE)-based LOC devices with physically isolated analytical andreporting regions were developed. Microchannels equipped withinterdigitated array (IDA) electrodes were designed to coupleindependent electrochemical reactions (in an analytical cell) tofluorescence response (in a separate reporter cell) using a closedBPE geometry. Proton-coupled electron transfer reactions wereinvestigated in the structure with integrated electrochemical pHmodulation. In the third applications, a dual-cell electrochromicdetector was developed in order to provide a simple detectionmethod for electrochemical sensing. In this application, thecolorimetric (electrochromic) indicator methyl viologen was coupledthrough a closed BPE to an analytical reaction in a separate cell.A smartphone was used to collect colorimetry data and provide asimple, fast, and reliable detection method with strong thepotential for point-of-care and real-time diagnosis applications.Finally, these electrochromic devices were employed for thedetection of common metabolites detection, such as glucose,lactate, and uric acid. By integrating multiple BPE components ontothe same device, it was possible to detect multiple analytes anddetermine their concentrations simultaneously using colorimetry.Selectivity and sensitivity of the detection were further improvedby introducing enzymes specific for target analytes and optimizingthe reporter cell size. Work in this thesis establishes that closedBPE devices can be coupled with electrochemical and opticaldetection to provide new opportunities for simple,…" @default.
• W2805107974 created "2018-06-13" @default.
• W2805107974 creator A5022854290 @default.
• W2805107974 date "2017-04-11" @default.
• W2805107974 modified "2023-09-27" @default.
• W2805107974 title "Integration of Optical and Electrochemical Detections on Lab-on-a-Chip Devices for Chemical and Biochemical Sensing" @default.
• W2805107974 hasPublicationYear "2017" @default.
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