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- W2805109405 endingPage "722" @default.
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- W2805109405 abstract "Lipid emulsion has been shown to be an effective treatment for systemic toxicity induced by local anesthetics, which is reflected in case reports. A systemic review and meta-analysis confirm the efficacy of this treatment. Investigators have suggested mechanisms associated with the lipid emulsion-mediated recovery of cardiovascular collapse caused by local anesthetic systemic toxicity; these mechanisms include lipid sink, a widely accepted theory in which highly soluble local anesthetics (particularly bupivacaine) are absorbed into the lipid phase of plasma from tissues (e.g., the heart) affected by local-anesthetic-induced toxicity; enhanced redistribution (lipid shuttle); fatty acid supply; reversal of mitochondrial dysfunction; inotropic effects; glycogen synthase kinase-3β phosphorylation associated with inhibition of the mitochondrial permeability transition pore opening; inhibition of nitric oxide release; and reversal of cardiac sodium channel blockade. The current review includes the following: 1) an introduction, 2) a list of the proposed mechanisms, 3) a discussion of the best lipid emulsion treatment for reversal of local anesthetic toxicity, 4) a description of the effect of epinephrine on lipid emulsion-mediated resuscitation, 5) a description of the recommended lipid emulsion treatment, and 6) a conclusion." @default.
- W2805109405 created "2018-06-13" @default.
- W2805109405 creator A5041671896 @default.
- W2805109405 creator A5068846031 @default.
- W2805109405 creator A5070630756 @default.
- W2805109405 creator A5091811890 @default.
- W2805109405 date "2018-01-01" @default.
- W2805109405 modified "2023-10-16" @default.
- W2805109405 title "Lipid Emulsion for Treating Local Anesthetic Systemic Toxicity" @default.
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