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- W2805110141 abstract "Rifamycin-derived drugs, including rifampin, rifabutin, rifapentine, and rifaximin, have long been used as first-line therapies for the treatment of tuberculosis and other deadly infections. However, the late steps leading to the biosynthesis of the industrially important rifamycin SV and B remain largely unknown. Here, we characterize a network of reactions underlying the biosynthesis of rifamycin SV, S, L, O, and B. The two-subunit transketolase Rif15 and the cytochrome P450 enzyme Rif16 are found to mediate, respectively, a unique C-O bond formation in rifamycin L and an atypical P450 ester-to-ether transformation from rifamycin L to B. Both reactions showcase interesting chemistries for these two widespread and well-studied enzyme families." @default.
- W2805110141 created "2018-06-13" @default.
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- W2805110141 date "2018-06-14" @default.
- W2805110141 modified "2023-10-15" @default.
- W2805110141 title "Deciphering the late steps of rifamycin biosynthesis" @default.
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- W2805110141 doi "https://doi.org/10.1038/s41467-018-04772-x" @default.
- W2805110141 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6002545" @default.
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