FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805111054> ?p ?o ?g. }

• W2805111054 abstract "Doxorubicin hydrochloride (DOX·HCl), an anthracycline glycoside antibiotic, exhibits low oral bioavailability due to active efflux from intestinal P-glycoprotein receptors. The oral administration of DOX remains a challenge hence; no oral formulation for DOX is marketed, till date.To improve the oral bioavailability of DOX through, preparation of a nanoformulation i.e. PEGylated-doxorubicin(DOX)-loaded-poly-lactic-co-glycolic acid (PLGA)-Nanoparticles (NPs) and to develop and validate an ultra-high performance liquid chromatography electrospray ionization-synapt mass spectrometric bioanalytical method (UHPLC/ESI-QTOF-MS/MS) for plasma (Wistar rats) DOX quantification.For chromatography, Waters ACQUITY UPLC™ along with a BEH C-18 column (2.1 mm × 100 mm; 1.7 μm), mobile phase conditions (acetonitrile: 0.1% formic acid::1:1 v/v) and flow rate (0.20 ml/min) was used. For analyte recovery from rat plasma, a liquid-liquid extraction method (LLE), using Acetonitrile: 5 mM ammonium acetate in a ratio of 6:4 v/v at pH 3.5, was used.Nanoformulation with a particle size (183.10 ± 7.41 nm), zeta potential (- 13.10 ± 1.04 mV), drug content (42.69 ± 1.97 µg/mg) and a spherical shape and smooth surface was developed. An elution time of 1.61 and 1.75 min along with a transition at m/z 544.42/397.27 and 528.46/321.41 were observed for DOX and internal standard (IS) Daunorubicin, respectively. In addition, a linear dynamic range with r2 ≥ 0.9985 over a concentration range of 1.00-2500.0 ng/ml was observed for different processes and parameters used in the study. Similarly a marked improvement i.e. 6.8 fold was observed, in PEGylated-DOX-PLGA-NPs as compared to DOX-S, in pharmacokinetics studies.The promising approach of PEGylated-DOX-PLGA-NPs may provide an alternate to intravenous therapy for better patient care." @default.
• W2805111054 created "2018-06-13" @default.
• W2805111054 creator A5010815670 @default.
• W2805111054 creator A5083459641 @default.
• W2805111054 creator A5087908803 @default.
• W2805111054 creator A5091249998 @default.
• W2805111054 date "2018-05-23" @default.
• W2805111054 modified "2023-10-14" @default.
• W2805111054 title "Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles" @default.
• W2805111054 cites W146281208 @default.
• W2805111054 cites W1495600513 @default.
• W2805111054 cites W1522410801 @default.
• W2805111054 cites W1713371841 @default.
• W2805111054 cites W1970314490 @default.
• W2805111054 cites W1970499331 @default.
• W2805111054 cites W1980808550 @default.
• W2805111054 cites W1990504585 @default.
• W2805111054 cites W1992966546 @default.
• W2805111054 cites W2000485927 @default.
• W2805111054 cites W2001629813 @default.
• W2805111054 cites W2017323111 @default.
• W2805111054 cites W2022793123 @default.
• W2805111054 cites W2024451301 @default.
• W2805111054 cites W2025995292 @default.
• W2805111054 cites W2030680926 @default.
• W2805111054 cites W2034574681 @default.
• W2805111054 cites W2037267091 @default.
• W2805111054 cites W2038774948 @default.
• W2805111054 cites W2038795968 @default.
• W2805111054 cites W2046494390 @default.
• W2805111054 cites W2049893592 @default.
• W2805111054 cites W2050181086 @default.
• W2805111054 cites W2052804020 @default.
• W2805111054 cites W2053102241 @default.
• W2805111054 cites W2055621667 @default.
• W2805111054 cites W2058958377 @default.
• W2805111054 cites W2059323563 @default.
• W2805111054 cites W2061123598 @default.
• W2805111054 cites W2062840864 @default.
• W2805111054 cites W2067689242 @default.
• W2805111054 cites W2072768012 @default.
• W2805111054 cites W2075663502 @default.
• W2805111054 cites W2076946660 @default.
• W2805111054 cites W2081631593 @default.
• W2805111054 cites W2086035683 @default.
• W2805111054 cites W2089489555 @default.
• W2805111054 cites W2102002215 @default.
• W2805111054 cites W2118878458 @default.
• W2805111054 cites W2129065382 @default.
• W2805111054 cites W2133756116 @default.
• W2805111054 cites W2135309893 @default.
• W2805111054 cites W2136615032 @default.
• W2805111054 cites W2137421007 @default.
• W2805111054 cites W2141056749 @default.
• W2805111054 cites W2152124377 @default.
• W2805111054 cites W2154309902 @default.
• W2805111054 cites W2154855352 @default.
• W2805111054 cites W2158610556 @default.
• W2805111054 cites W2160551609 @default.
• W2805111054 cites W2167357429 @default.
• W2805111054 cites W2291638988 @default.
• W2805111054 cites W2293607107 @default.
• W2805111054 cites W2332972932 @default.
• W2805111054 cites W2581463643 @default.
• W2805111054 cites W2612247067 @default.
• W2805111054 cites W2750326387 @default.
• W2805111054 cites W560516700 @default.
• W2805111054 cites W3144870107 @default.
• W2805111054 doi "https://doi.org/10.1186/s13065-018-0434-1" @default.
• W2805111054 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5966352" @default.
• W2805111054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29796830" @default.
• W2805111054 hasPublicationYear "2018" @default.
• W2805111054 type Work @default.
• W2805111054 sameAs 2805111054 @default.
• W2805111054 citedByCount "52" @default.
• W2805111054 countsByYear W28051110542018 @default.
• W2805111054 countsByYear W28051110542019 @default.
• W2805111054 countsByYear W28051110542020 @default.
• W2805111054 countsByYear W28051110542021 @default.
• W2805111054 countsByYear W28051110542022 @default.
• W2805111054 countsByYear W28051110542023 @default.
• W2805111054 crossrefType "journal-article" @default.
• W2805111054 hasAuthorship W2805111054A5010815670 @default.
• W2805111054 hasAuthorship W2805111054A5083459641 @default.
• W2805111054 hasAuthorship W2805111054A5087908803 @default.
• W2805111054 hasAuthorship W2805111054A5091249998 @default.
• W2805111054 hasBestOaLocation W28051110541 @default.
• W2805111054 hasConcept C119128265 @default.
• W2805111054 hasConcept C141071460 @default.
• W2805111054 hasConcept C147789679 @default.
• W2805111054 hasConcept C162356407 @default.
• W2805111054 hasConcept C181389837 @default.
• W2805111054 hasConcept C185592680 @default.
• W2805111054 hasConcept C187530423 @default.
• W2805111054 hasConcept C2776694085 @default.
• W2805111054 hasConcept C2777379063 @default.
• W2805111054 hasConcept C2781303535 @default.
• W2805111054 hasConcept C2909829705 @default.
• W2805111054 hasConcept C40684141 @default.
• W2805111054 hasConcept C43617362 @default.

• next