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- W2805114637 abstract "Clathrin-mediated endocytosis is an essential cellular function in all eukaryotes that is driven by a self-assembled macromolecular machine of over 50 different proteins in tens to hundreds of copies. How these proteins are organized to produce endocytic vesicles with high precision and efficiency is not understood. Here, we developed high-throughput superresolution microscopy to reconstruct the nanoscale structural organization of 23 endocytic proteins from over 100,000 endocytic sites in yeast. We found that proteins assemble by radially ordered recruitment according to function. WASP family proteins form a circular nanoscale template on the membrane to spatially control actin nucleation during vesicle formation. Mathematical modeling of actin polymerization showed that this WASP nano-template optimizes force generation for membrane invagination and substantially increases the efficiency of endocytosis. Such nanoscale pre-patterning of actin nucleation may represent a general design principle for directional force generation in membrane remodeling processes such as during cell migration and division." @default.
- W2805114637 created "2018-06-13" @default.
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- W2805114637 date "2018-08-01" @default.
- W2805114637 modified "2023-10-16" @default.
- W2805114637 title "Systematic Nanoscale Analysis of Endocytosis Links Efficient Vesicle Formation to Patterned Actin Nucleation" @default.
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- W2805114637 doi "https://doi.org/10.1016/j.cell.2018.06.032" @default.
- W2805114637 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6086932" @default.
- W2805114637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30057119" @default.
- W2805114637 hasPublicationYear "2018" @default.
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