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• W2805118976 abstract "Flaviviruses have evolved complex mechanisms to evade the mammalian host immune systems including the RIG-I (retinoic acid-inducible gene I) like receptor (RLR) signaling. Zika virus (ZIKV) is a re-emerging flavivirus that is associated with severe neonatal microcephaly and adult Guillain-Barre syndrome. However, the molecular mechanisms underlying ZIKV pathogenesis remain poorly defined. Here we report that ZIKV non-structural protein 4A (NS4A) impairs the RLR-mitochondrial antiviral-signaling protein (MAVS) interaction and subsequent induction of antiviral immune responses. In human trophoblasts, both RIG-I and melanoma differentiation-associated protein 5 (MDA5) contribute to type I interferon (IFN) induction and control ZIKV replication. Type I IFN induction by ZIKV is almost completely abolished in MAVS-/- cells. NS4A represses RLR-, but not Toll-like receptor-mediated immune responses. NS4A specifically binds the N-terminal caspase activation and recruitment domain (CARD) of MAVS and thus blocks its accessibility by RLRs. Our study provides in-depth understanding of the molecular mechanisms of immune evasion by ZIKV and its pathogenesis." @default.
• W2805118976 created "2018-06-13" @default.
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• W2805118976 date "2018-06-25" @default.
• W2805118976 modified "2023-10-12" @default.
• W2805118976 title "Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS Signaling" @default.
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• W2805118976 doi "https://doi.org/10.3389/fmicb.2018.01350" @default.
• W2805118976 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6026624" @default.
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