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• W2805146172 abstract "Programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) is a significant immune checkpoint, and the dysfunction of this axis contributes to tumor metastasis and immune escape. PI3K/Akt/mTOR and MAPK signal network induces PD-1/PD-L1 expression and facilitates tumor progression. Transcriptional factors such as hypoxia induced factors, PTEN, p53, CDK5, BRD4, STAT modulate PD-1/PD-L1 expression. PD-1/PD-L1 level is also regulated via epigenetic and post-translational manner. The underlying mechanisms mentioned above may provide potential targets for tumor treatment. At present, the combination therapy of PD-1/PD-L1 monoclonal antibodies plus small molecular inhibitors has achieved good outcomes in tumor treatment." @default.
• W2805146172 created "2018-06-13" @default.
• W2805146172 creator A5038602173 @default.
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• W2805146172 date "2018-01-01" @default.
• W2805146172 modified "2023-09-26" @default.
• W2805146172 title "PD-1/ PD-L1 调控及靶向免疫治疗研究进展" @default.
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• W2805146172 doi "https://doi.org/10.24920/21804" @default.
• W2805146172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30266108" @default.
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