FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805147785> ?p ?o ?g. }

• W2805147785 endingPage "380" @default.
• W2805147785 startingPage "374" @default.
• W2805147785 abstract "The efficiency of the immune system has been shaped throughout the evolutionary process allowing adaptations. In a Plasmodium vivax infection, the host attempts to develop an innate immune response to keep in check the parasite that is associated with inflammatory and regulatory processes. Production of pro-inflammatory and regulatory cytokines simultaneously appears to be a balancing mechanism for the host to prevent the onset of severe disease. Changes in the dynamics of circulating cytokines production can influence the pathogenesis, severity of the disease and episodes of recurrent Plasmodium vivax malaria (Pv-malaria). A cross-sectional study was conducted in endemic areas for Pv-malaria in the Amazonas State, Brazil. Several SNPs in TLR genes were genotyped by PCR-RFLP in 137 patients infected with P. vivax. Circulating cytokines IL-6, TNF, IL-2, IL-10, IFN-γ and IL-4 were measured by CBA. Influence of the studied SNPs on circulating cytokines was investigated by applying the Kruskal-Wallis test followed by Dunns' multiple comparison post-test. A Spearman correlation test also was performed to elaborate circulating cytokine networks and to demonstrate the level of interaction between each molecule. Individuals with genotypes A/G (TLR4 A299G), C/C (TLR6 S249P) and T/T (TLR9 -1486C/T) appear to produce less/gain IL-6, IFN-γ, IL-10, IL-2 and IL-4 compared to patients with wild-type and heterozygous genotypes. In addition, these genotypes seem to influence the interaction network between the molecules studied, causing a lower interaction, absence or even negative interaction between the cytokines. Data presented in this study suggests the influence of polymorphisms TLR4 (A299G), TLR6 (S249P) and TLR9 (-1486C/T) on the production of circulating cytokines during Pv-malaria." @default.
• W2805147785 created "2018-06-13" @default.
• W2805147785 creator A5000615899 @default.
• W2805147785 creator A5001446475 @default.
• W2805147785 creator A5016496013 @default.
• W2805147785 creator A5021876583 @default.
• W2805147785 creator A5024161412 @default.
• W2805147785 creator A5043240695 @default.
• W2805147785 creator A5044422599 @default.
• W2805147785 creator A5073952230 @default.
• W2805147785 creator A5077065332 @default.
• W2805147785 creator A5083367922 @default.
• W2805147785 creator A5085880705 @default.
• W2805147785 date "2018-10-01" @default.
• W2805147785 modified "2023-10-14" @default.
• W2805147785 title "Polymorphisms in TLRs influence circulating cytokines production in Plasmodium vivax malaria" @default.
• W2805147785 cites W1483558783 @default.
• W2805147785 cites W1648719203 @default.
• W2805147785 cites W1989185921 @default.
• W2805147785 cites W1994364461 @default.
• W2805147785 cites W1994942139 @default.
• W2805147785 cites W1995744610 @default.
• W2805147785 cites W2003276424 @default.
• W2805147785 cites W2005234042 @default.
• W2805147785 cites W2006509079 @default.
• W2805147785 cites W2007130652 @default.
• W2805147785 cites W2018505592 @default.
• W2805147785 cites W2020755315 @default.
• W2805147785 cites W2023299675 @default.
• W2805147785 cites W2025928231 @default.
• W2805147785 cites W2034795425 @default.
• W2805147785 cites W2036384654 @default.
• W2805147785 cites W2038486513 @default.
• W2805147785 cites W2048992607 @default.
• W2805147785 cites W2049981162 @default.
• W2805147785 cites W2056704040 @default.
• W2805147785 cites W2058675190 @default.
• W2805147785 cites W2060732537 @default.
• W2805147785 cites W2075942059 @default.
• W2805147785 cites W2077857097 @default.
• W2805147785 cites W2085946003 @default.
• W2805147785 cites W2088720756 @default.
• W2805147785 cites W2088824647 @default.
• W2805147785 cites W2094989950 @default.
• W2805147785 cites W2096839777 @default.
• W2805147785 cites W2100359781 @default.
• W2805147785 cites W2104577931 @default.
• W2805147785 cites W2106852899 @default.
• W2805147785 cites W2109491705 @default.
• W2805147785 cites W2113341236 @default.
• W2805147785 cites W2114216755 @default.
• W2805147785 cites W2116141139 @default.
• W2805147785 cites W2121675649 @default.
• W2805147785 cites W2127533700 @default.
• W2805147785 cites W2129941942 @default.
• W2805147785 cites W2133539151 @default.
• W2805147785 cites W2133972984 @default.
• W2805147785 cites W2134542865 @default.
• W2805147785 cites W2138295263 @default.
• W2805147785 cites W2141047461 @default.
• W2805147785 cites W2143838330 @default.
• W2805147785 cites W2146130945 @default.
• W2805147785 cites W2146859644 @default.
• W2805147785 cites W2149024057 @default.
• W2805147785 cites W2150195134 @default.
• W2805147785 cites W2152507925 @default.
• W2805147785 cites W2160660031 @default.
• W2805147785 cites W2162257455 @default.
• W2805147785 cites W2164786710 @default.
• W2805147785 cites W2167096209 @default.
• W2805147785 cites W2167751983 @default.
• W2805147785 cites W2229078116 @default.
• W2805147785 cites W2231303050 @default.
• W2805147785 cites W2511541703 @default.
• W2805147785 cites W2619338344 @default.
• W2805147785 cites W2752567914 @default.
• W2805147785 doi "https://doi.org/10.1016/j.cyto.2018.04.008" @default.
• W2805147785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29656958" @default.
• W2805147785 hasPublicationYear "2018" @default.
• W2805147785 type Work @default.
• W2805147785 sameAs 2805147785 @default.
• W2805147785 citedByCount "16" @default.
• W2805147785 countsByYear W28051477852019 @default.
• W2805147785 countsByYear W28051477852020 @default.
• W2805147785 countsByYear W28051477852021 @default.
• W2805147785 countsByYear W28051477852022 @default.
• W2805147785 countsByYear W28051477852023 @default.
• W2805147785 crossrefType "journal-article" @default.
• W2805147785 hasAuthorship W2805147785A5000615899 @default.
• W2805147785 hasAuthorship W2805147785A5001446475 @default.
• W2805147785 hasAuthorship W2805147785A5016496013 @default.
• W2805147785 hasAuthorship W2805147785A5021876583 @default.
• W2805147785 hasAuthorship W2805147785A5024161412 @default.
• W2805147785 hasAuthorship W2805147785A5043240695 @default.
• W2805147785 hasAuthorship W2805147785A5044422599 @default.
• W2805147785 hasAuthorship W2805147785A5073952230 @default.
• W2805147785 hasAuthorship W2805147785A5077065332 @default.
• W2805147785 hasAuthorship W2805147785A5083367922 @default.

• next