Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805152796> ?p ?o ?g. }
- W2805152796 abstract "Abstract The molecular mechanisms underlying vascular regeneration and repair are largely unknown. To gain insight into this process, we developed a method of intima denudation, characterized the progression of endothelial healing, and performed transcriptome analysis over time. Next-generation RNA sequencing (RNAseq) provided a quantitative and unbiased gene expression profile during in vivo regeneration following denudation injury. Our data indicate that shortly after injury, cells immediately adjacent to the wound mount a robust and rapid response with upregulation of genes like Jun , Fos , Myc , as well as cell adhesion genes. This was quickly followed by a wave of proliferative genes. After completion of endothelial healing a vigorous array of extracellular matrix transcripts were upregulated. Gene ontology enrichment and protein network analysis were used to identify transcriptional profiles over time. Further data mining revealed four distinct stages of regeneration: shock, proliferation, acclimation, and maturation. The transcriptional signature of those stages provides insight into the regenerative machinery responsible for arterial repair under normal physiologic conditions." @default.
- W2805152796 created "2018-06-13" @default.
- W2805152796 creator A5002883678 @default.
- W2805152796 creator A5019581784 @default.
- W2805152796 creator A5033893801 @default.
- W2805152796 creator A5039961461 @default.
- W2805152796 creator A5064132444 @default.
- W2805152796 creator A5069878087 @default.
- W2805152796 date "2018-04-03" @default.
- W2805152796 modified "2023-10-13" @default.
- W2805152796 title "A multi-step transcriptional cascade underlies vascular regeneration in vivo" @default.
- W2805152796 cites W1546322748 @default.
- W2805152796 cites W1582020170 @default.
- W2805152796 cites W1925956231 @default.
- W2805152796 cites W1949173079 @default.
- W2805152796 cites W1969028149 @default.
- W2805152796 cites W1971324461 @default.
- W2805152796 cites W1973094248 @default.
- W2805152796 cites W1979475230 @default.
- W2805152796 cites W1991341847 @default.
- W2805152796 cites W1992112921 @default.
- W2805152796 cites W1993523135 @default.
- W2805152796 cites W2007444438 @default.
- W2805152796 cites W2009090099 @default.
- W2805152796 cites W2013860138 @default.
- W2805152796 cites W2022745705 @default.
- W2805152796 cites W2023072510 @default.
- W2805152796 cites W2029610231 @default.
- W2805152796 cites W2032244429 @default.
- W2805152796 cites W2036034164 @default.
- W2805152796 cites W2038871793 @default.
- W2805152796 cites W2039344188 @default.
- W2805152796 cites W2058015990 @default.
- W2805152796 cites W2062770053 @default.
- W2805152796 cites W2070381506 @default.
- W2805152796 cites W2072319964 @default.
- W2805152796 cites W2073551059 @default.
- W2805152796 cites W2082873393 @default.
- W2805152796 cites W2096086497 @default.
- W2805152796 cites W2096166765 @default.
- W2805152796 cites W2096173332 @default.
- W2805152796 cites W2102278945 @default.
- W2805152796 cites W2103839593 @default.
- W2805152796 cites W2104238956 @default.
- W2805152796 cites W2108902016 @default.
- W2805152796 cites W2110711494 @default.
- W2805152796 cites W2112540241 @default.
- W2805152796 cites W2113111549 @default.
- W2805152796 cites W2118272737 @default.
- W2805152796 cites W2125418297 @default.
- W2805152796 cites W2128098876 @default.
- W2805152796 cites W2129631223 @default.
- W2805152796 cites W2131461932 @default.
- W2805152796 cites W2144026946 @default.
- W2805152796 cites W2158217645 @default.
- W2805152796 cites W2159642184 @default.
- W2805152796 cites W2162499074 @default.
- W2805152796 cites W2179438025 @default.
- W2805152796 cites W2250688633 @default.
- W2805152796 cites W2343439038 @default.
- W2805152796 cites W2346143774 @default.
- W2805152796 cites W2486397717 @default.
- W2805152796 cites W2510079342 @default.
- W2805152796 cites W2524178063 @default.
- W2805152796 cites W2554867710 @default.
- W2805152796 cites W2559909608 @default.
- W2805152796 cites W2567299692 @default.
- W2805152796 cites W2586352915 @default.
- W2805152796 cites W2597243982 @default.
- W2805152796 cites W2793437699 @default.
- W2805152796 cites W4252232449 @default.
- W2805152796 doi "https://doi.org/10.1038/s41598-018-23653-3" @default.
- W2805152796 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5882937" @default.
- W2805152796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29615716" @default.
- W2805152796 hasPublicationYear "2018" @default.
- W2805152796 type Work @default.
- W2805152796 sameAs 2805152796 @default.
- W2805152796 citedByCount "9" @default.
- W2805152796 countsByYear W28051527962018 @default.
- W2805152796 countsByYear W28051527962019 @default.
- W2805152796 countsByYear W28051527962020 @default.
- W2805152796 countsByYear W28051527962021 @default.
- W2805152796 countsByYear W28051527962022 @default.
- W2805152796 countsByYear W28051527962023 @default.
- W2805152796 crossrefType "journal-article" @default.
- W2805152796 hasAuthorship W2805152796A5002883678 @default.
- W2805152796 hasAuthorship W2805152796A5019581784 @default.
- W2805152796 hasAuthorship W2805152796A5033893801 @default.
- W2805152796 hasAuthorship W2805152796A5039961461 @default.
- W2805152796 hasAuthorship W2805152796A5064132444 @default.
- W2805152796 hasAuthorship W2805152796A5069878087 @default.
- W2805152796 hasBestOaLocation W28051527961 @default.
- W2805152796 hasConcept C104317684 @default.
- W2805152796 hasConcept C127561419 @default.
- W2805152796 hasConcept C150194340 @default.
- W2805152796 hasConcept C162317418 @default.
- W2805152796 hasConcept C171056886 @default.
- W2805152796 hasConcept C189165786 @default.
- W2805152796 hasConcept C2780269544 @default.
- W2805152796 hasConcept C54355233 @default.