FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805175894> ?p ?o ?g. }

• W2805175894 endingPage "707" @default.
• W2805175894 startingPage "698" @default.
• W2805175894 abstract "Pharmacokinetics of voriconazole, an anti-fungal agent, was determined in collagen-induced arthritic (CIA) and healthy DBA/1J mice. CIA was confirmed in DBA/1J mice by clinical scoring and histological analysis.In vivo oral pharmacokinetic study (3 mg/kg) and in vitro stability assessment in liver microsomes were performed in CIA vs. healthy DBA/1J mice. Additionally, hepatic portal vein cannulated (HPVC) CIA and healthy mice were used to clarify the role of gut first-pass effect. Voriconazole/N-oxide metabolite was measured in plasma and in vitro samples using liquid chromatography tandem-mass spectrometry method.Voriconazole exposure was reduced in CIA by 27% as compared to healthy mice. Formation of voriconazole N-oxide was higher in CIA mice as evidenced by higher molar Cmax ratio (i.e. metabolite/parent) of 2.08 vs. 1.66 in healthy mice. Because voriconazole was stable in microsomes, involvement of presystemic gut metabolism was suspected for decreased voriconazole exposure and formation of higher molar ratio of metabolite. HPVC work revealed higher formation of voriconazole N-oxide in CIA relative to healthy mice resulting in Cmax/AUC ratios of 0.41/0.54 and 0.08/0.17, respectively, confirming first-pass effect.The findings may have implications in the clinical therapy of arthritis patients who are concomitantly given voriconazole for the management of fungal infections." @default.
• W2805175894 created "2018-06-13" @default.
• W2805175894 creator A5000842580 @default.
• W2805175894 creator A5001761027 @default.
• W2805175894 creator A5012185839 @default.
• W2805175894 creator A5017150008 @default.
• W2805175894 creator A5038745885 @default.
• W2805175894 creator A5043448634 @default.
• W2805175894 creator A5049492180 @default.
• W2805175894 creator A5056704911 @default.
• W2805175894 creator A5076461298 @default.
• W2805175894 creator A5088511997 @default.
• W2805175894 date "2018-07-30" @default.
• W2805175894 modified "2023-10-16" @default.
• W2805175894 title "Impact of collagen-induced arthritis on the pharmacokinetic disposition of voriconazole, a widely used antifungal agent: in vitro and in vivo investigations in DBA/1J mice" @default.
• W2805175894 cites W1970063069 @default.
• W2805175894 cites W1987069059 @default.
• W2805175894 cites W1996806440 @default.
• W2805175894 cites W2007970998 @default.
• W2805175894 cites W2008601710 @default.
• W2805175894 cites W2013000822 @default.
• W2805175894 cites W2025117799 @default.
• W2805175894 cites W2036323185 @default.
• W2805175894 cites W2079899732 @default.
• W2805175894 cites W2098187188 @default.
• W2805175894 cites W2101089712 @default.
• W2805175894 cites W2124505897 @default.
• W2805175894 cites W2140073887 @default.
• W2805175894 cites W2146607274 @default.
• W2805175894 cites W2158672854 @default.
• W2805175894 cites W2244985839 @default.
• W2805175894 cites W2400119402 @default.
• W2805175894 cites W2468426553 @default.
• W2805175894 cites W2520882187 @default.
• W2805175894 cites W2532989966 @default.
• W2805175894 cites W2554134408 @default.
• W2805175894 cites W2566509413 @default.
• W2805175894 cites W572885427 @default.
• W2805175894 doi "https://doi.org/10.1080/00498254.2018.1485989" @default.
• W2805175894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29873579" @default.
• W2805175894 hasPublicationYear "2018" @default.
• W2805175894 type Work @default.
• W2805175894 sameAs 2805175894 @default.
• W2805175894 citedByCount "0" @default.
• W2805175894 crossrefType "journal-article" @default.
• W2805175894 hasAuthorship W2805175894A5000842580 @default.
• W2805175894 hasAuthorship W2805175894A5001761027 @default.
• W2805175894 hasAuthorship W2805175894A5012185839 @default.
• W2805175894 hasAuthorship W2805175894A5017150008 @default.
• W2805175894 hasAuthorship W2805175894A5038745885 @default.
• W2805175894 hasAuthorship W2805175894A5043448634 @default.
• W2805175894 hasAuthorship W2805175894A5049492180 @default.
• W2805175894 hasAuthorship W2805175894A5056704911 @default.
• W2805175894 hasAuthorship W2805175894A5076461298 @default.
• W2805175894 hasAuthorship W2805175894A5088511997 @default.
• W2805175894 hasBestOaLocation W28051758942 @default.
• W2805175894 hasConcept C112705442 @default.
• W2805175894 hasConcept C126322002 @default.
• W2805175894 hasConcept C150903083 @default.
• W2805175894 hasConcept C16005928 @default.
• W2805175894 hasConcept C185592680 @default.
• W2805175894 hasConcept C202751555 @default.
• W2805175894 hasConcept C207001950 @default.
• W2805175894 hasConcept C22979827 @default.
• W2805175894 hasConcept C2777077863 @default.
• W2805175894 hasConcept C2777477808 @default.
• W2805175894 hasConcept C2779548794 @default.
• W2805175894 hasConcept C2780690907 @default.
• W2805175894 hasConcept C55493867 @default.
• W2805175894 hasConcept C71924100 @default.
• W2805175894 hasConcept C86803240 @default.
• W2805175894 hasConcept C98274493 @default.
• W2805175894 hasConceptScore W2805175894C112705442 @default.
• W2805175894 hasConceptScore W2805175894C126322002 @default.
• W2805175894 hasConceptScore W2805175894C150903083 @default.
• W2805175894 hasConceptScore W2805175894C16005928 @default.
• W2805175894 hasConceptScore W2805175894C185592680 @default.
• W2805175894 hasConceptScore W2805175894C202751555 @default.
• W2805175894 hasConceptScore W2805175894C207001950 @default.
• W2805175894 hasConceptScore W2805175894C22979827 @default.
• W2805175894 hasConceptScore W2805175894C2777077863 @default.
• W2805175894 hasConceptScore W2805175894C2777477808 @default.
• W2805175894 hasConceptScore W2805175894C2779548794 @default.
• W2805175894 hasConceptScore W2805175894C2780690907 @default.
• W2805175894 hasConceptScore W2805175894C55493867 @default.
• W2805175894 hasConceptScore W2805175894C71924100 @default.
• W2805175894 hasConceptScore W2805175894C86803240 @default.
• W2805175894 hasConceptScore W2805175894C98274493 @default.
• W2805175894 hasIssue "6" @default.
• W2805175894 hasLocation W28051758941 @default.
• W2805175894 hasLocation W28051758942 @default.
• W2805175894 hasLocation W28051758943 @default.
• W2805175894 hasOpenAccess W2805175894 @default.
• W2805175894 hasPrimaryLocation W28051758941 @default.
• W2805175894 hasRelatedWork W1985758966 @default.
• W2805175894 hasRelatedWork W2028112905 @default.
• W2805175894 hasRelatedWork W2056938528 @default.
• W2805175894 hasRelatedWork W2057097799 @default.

• next