FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805179249> ?p ?o ?g. }

• W2805179249 endingPage "3270" @default.
• W2805179249 startingPage "3265" @default.
• W2805179249 abstract "Aurora kinases as regulators of cell division have become promising therapeutic targets recently. Here we report novel, low molecular weight benzothiophene-3-carboxamide derivatives designed and optimized for inhibiting Aurora kinases. The most effective compound 36 inhibits Aurora kinases in vitro in the nanomolar range and diminishes HCT 116 cell viability blocking cytokinesis and inducing apoptosis. According to western blot analysis, the lead molecule inhibits Aurora kinases equipotently to VX-680 (Tozasertib) and similarly synergizes with other targeted drugs." @default.
• W2805179249 created "2018-06-13" @default.
• W2805179249 creator A5021170936 @default.
• W2805179249 creator A5025613561 @default.
• W2805179249 creator A5030233937 @default.
• W2805179249 creator A5039321576 @default.
• W2805179249 creator A5041096747 @default.
• W2805179249 creator A5051188126 @default.
• W2805179249 creator A5063435633 @default.
• W2805179249 creator A5065080483 @default.
• W2805179249 creator A5067068981 @default.
• W2805179249 creator A5068866500 @default.
• W2805179249 creator A5073849664 @default.
• W2805179249 creator A5079773434 @default.
• W2805179249 creator A5088137210 @default.
• W2805179249 date "2018-10-01" @default.
• W2805179249 modified "2023-10-18" @default.
• W2805179249 title "Discovery and optimization of novel benzothiophene-3-carboxamides as highly potent inhibitors of Aurora kinases A and B" @default.
• W2805179249 cites W1657157395 @default.
• W2805179249 cites W1966521331 @default.
• W2805179249 cites W1984507712 @default.
• W2805179249 cites W1985338536 @default.
• W2805179249 cites W1990428670 @default.
• W2805179249 cites W1994488152 @default.
• W2805179249 cites W1997492224 @default.
• W2805179249 cites W2006811655 @default.
• W2805179249 cites W2012701344 @default.
• W2805179249 cites W2016462887 @default.
• W2805179249 cites W2035845541 @default.
• W2805179249 cites W2044433401 @default.
• W2805179249 cites W2064261028 @default.
• W2805179249 cites W2067115862 @default.
• W2805179249 cites W2067352806 @default.
• W2805179249 cites W2069910776 @default.
• W2805179249 cites W2071156666 @default.
• W2805179249 cites W2072364504 @default.
• W2805179249 cites W2083352151 @default.
• W2805179249 cites W2093549611 @default.
• W2805179249 cites W2097805301 @default.
• W2805179249 cites W2101117526 @default.
• W2805179249 cites W2106942695 @default.
• W2805179249 cites W2121246511 @default.
• W2805179249 cites W2128553601 @default.
• W2805179249 cites W2134064448 @default.
• W2805179249 cites W2137151867 @default.
• W2805179249 cites W2140556409 @default.
• W2805179249 cites W2166576935 @default.
• W2805179249 cites W2247377681 @default.
• W2805179249 cites W2324154850 @default.
• W2805179249 cites W325556838 @default.
• W2805179249 doi "https://doi.org/10.1016/j.bmcl.2018.05.064" @default.
• W2805179249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30143423" @default.
• W2805179249 hasPublicationYear "2018" @default.
• W2805179249 type Work @default.
• W2805179249 sameAs 2805179249 @default.
• W2805179249 citedByCount "3" @default.
• W2805179249 countsByYear W28051792492021 @default.
• W2805179249 countsByYear W28051792492022 @default.
• W2805179249 crossrefType "journal-article" @default.
• W2805179249 hasAuthorship W2805179249A5021170936 @default.
• W2805179249 hasAuthorship W2805179249A5025613561 @default.
• W2805179249 hasAuthorship W2805179249A5030233937 @default.
• W2805179249 hasAuthorship W2805179249A5039321576 @default.
• W2805179249 hasAuthorship W2805179249A5041096747 @default.
• W2805179249 hasAuthorship W2805179249A5051188126 @default.
• W2805179249 hasAuthorship W2805179249A5063435633 @default.
• W2805179249 hasAuthorship W2805179249A5065080483 @default.
• W2805179249 hasAuthorship W2805179249A5067068981 @default.
• W2805179249 hasAuthorship W2805179249A5068866500 @default.
• W2805179249 hasAuthorship W2805179249A5073849664 @default.
• W2805179249 hasAuthorship W2805179249A5079773434 @default.
• W2805179249 hasAuthorship W2805179249A5088137210 @default.
• W2805179249 hasConcept C141937037 @default.
• W2805179249 hasConcept C1491633281 @default.
• W2805179249 hasConcept C161624437 @default.
• W2805179249 hasConcept C178790620 @default.
• W2805179249 hasConcept C184235292 @default.
• W2805179249 hasConcept C185592680 @default.
• W2805179249 hasConcept C190283241 @default.
• W2805179249 hasConcept C20552341 @default.
• W2805179249 hasConcept C2779303843 @default.
• W2805179249 hasConcept C2779953032 @default.
• W2805179249 hasConcept C2780808130 @default.
• W2805179249 hasConcept C29537977 @default.
• W2805179249 hasConcept C45472230 @default.
• W2805179249 hasConcept C55493867 @default.
• W2805179249 hasConcept C85813293 @default.
• W2805179249 hasConceptScore W2805179249C141937037 @default.
• W2805179249 hasConceptScore W2805179249C1491633281 @default.
• W2805179249 hasConceptScore W2805179249C161624437 @default.
• W2805179249 hasConceptScore W2805179249C178790620 @default.
• W2805179249 hasConceptScore W2805179249C184235292 @default.
• W2805179249 hasConceptScore W2805179249C185592680 @default.
• W2805179249 hasConceptScore W2805179249C190283241 @default.
• W2805179249 hasConceptScore W2805179249C20552341 @default.
• W2805179249 hasConceptScore W2805179249C2779303843 @default.
• W2805179249 hasConceptScore W2805179249C2779953032 @default.
• W2805179249 hasConceptScore W2805179249C2780808130 @default.

• next