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• W2805207231 abstract "Novel Insights into the Pathophysiology and Treatment of Obstructive Sleep Apnea Epidemiology of sleep apnea/hypopnea syndrome and sleep-disordered breathingPoul J Jennum & Renata L RihaPoul J JennumPoul J Jennum is Chief Consultant at the Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Glostrup Hospital (Denmark) and Professor at the Faculty of Health Sciences, University of Copenhagen (Denmark). His main research interests are sleep medicine, neurophysiological methods and continued monitoring of physiological signals. He has published more than 160 peer-reviewed papers and is a member and Chairman for several national and international committees.Search for more papers by this author & Renata L RihaRenata L Riha has been a Consultant in Sleep and Respiratory Medicine at the Royal Infirmary of Edinburgh (UK) since 2004, and completed her MD at the Department of Sleep Medicine with Professor Sir Neil Douglas. She is an Honorary Reader at the University of Edinburgh (UK). She qualified in medicine at the University of Queensland (Brisbane, Australia) and completed her specialist training in respiratory and sleep medicine in Australia. She is a Fellow of the Royal Australasian College of Physicians and a Fellow of the Royal College of Physicians in Edinburgh.Search for more papers by this authorPublished Online:3 Apr 2014https://doi.org/10.2217/ebo.13.622AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinkedInReddit View chapterAbstract: Epidemiological studies have revealed a high prevalence of sleep-disordered breathing (SDB) in the community (≥20%). A subset of those with SDB have concurrent symptoms of excessive daytime sleepiness directly attributable to their nocturnal breathing disorder and are classified as having obstructive sleep apnea/hypopnea syndrome (2–4% of the middle-aged population). There is strong evidence for the association of obstructive sleep apnea syndrome with cardiovascular and cerebrovascular morbidity, and as adverse public health consequences are well regarded. Treatment and diagnosis have remained largely unchanged over the past 25 years. In moderate-to-severe obstructive sleep apnea/hypopnea syndrome, treatment with continuous positive airway pressure has been shown to be effective. Questions remain as to how to best screen patients with SDB; should time-consuming diagnostic procedures with high sensitivity and specificity be employed, or should simpler methods be applied for screening populations at risk (e.g., in the primary-care sector)? References1 Young T , Palta M , Dempsey J , Skatrud J , Weber S , Badr S . The occurrence of sleep-disordered breathing among middle-aged adults . N. Engl. J. Med. 328 (17) , 1230 – 1235 (1993) . Crossref, Medline, CAS, Google Scholar2 Jennum P , Sjol A . 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