Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805226990> ?p ?o ?g. }
- W2805226990 abstract "Abstract Chondrocytes at different maturation states in the growth plate produce matrix vesicles (MVs), membrane organelles found in the extracellular matrix, with a wide range of contents, such as matrix processing enzymes and receptors for hormones. We have shown that MVs harvested from growth zone (GC) chondrocyte cultures contain abundant small RNAs, including miRNAs. Here, we determined whether RNA also exists in MVs produced by less mature resting zone (RC) chondrocytes and, if so, whether it differs from the RNA in MVs produced by GC cells. Our results showed that RNA, small RNA specifically, was present in RC-MVs, and it was well-protected from RNase by the phospholipid membrane. A group of miRNAs was enriched in RC-MVs compared RC-cells, suggesting that miRNAs are selectively packaged into MVs. High throughput array and RNA sequencing showed that ~39% miRNAs were differentially expressed between RC-MVs and GC-MVs. Individual RT-qPCR also confirmed that miR-122-5p and miR-150-5p were expressed at significantly higher levels in RC-MVs compared to GC-MVs. This study showed that growth plate chondrocytes at different differentiation stages produce different MVs with different miRNA contents, further supporting extracellular vesicle miRNAs play a role as “matrisomes” that mediate the cell–cell communication in cartilage and bone development." @default.
- W2805226990 created "2018-06-13" @default.
- W2805226990 creator A5012331816 @default.
- W2805226990 creator A5017082027 @default.
- W2805226990 creator A5019912186 @default.
- W2805226990 creator A5029880479 @default.
- W2805226990 creator A5037078524 @default.
- W2805226990 creator A5041223114 @default.
- W2805226990 creator A5052368052 @default.
- W2805226990 creator A5062088157 @default.
- W2805226990 date "2018-02-26" @default.
- W2805226990 modified "2023-10-14" @default.
- W2805226990 title "MicroRNA Contents in Matrix Vesicles Produced by Growth Plate Chondrocytes are Cell Maturation Dependent" @default.
- W2805226990 cites W144423133 @default.
- W2805226990 cites W1530516996 @default.
- W2805226990 cites W1557531720 @default.
- W2805226990 cites W1605302895 @default.
- W2805226990 cites W1607423821 @default.
- W2805226990 cites W1666322469 @default.
- W2805226990 cites W1772547922 @default.
- W2805226990 cites W1965979895 @default.
- W2805226990 cites W1966451804 @default.
- W2805226990 cites W1968536205 @default.
- W2805226990 cites W1974509147 @default.
- W2805226990 cites W1984018226 @default.
- W2805226990 cites W1988288781 @default.
- W2805226990 cites W1999566158 @default.
- W2805226990 cites W2012716377 @default.
- W2805226990 cites W2016547417 @default.
- W2805226990 cites W201863201 @default.
- W2805226990 cites W2023115791 @default.
- W2805226990 cites W2024626991 @default.
- W2805226990 cites W2027011631 @default.
- W2805226990 cites W2035716585 @default.
- W2805226990 cites W2042187005 @default.
- W2805226990 cites W2042932723 @default.
- W2805226990 cites W2043525438 @default.
- W2805226990 cites W2046126395 @default.
- W2805226990 cites W2048383047 @default.
- W2805226990 cites W2048868013 @default.
- W2805226990 cites W2057058773 @default.
- W2805226990 cites W2057650091 @default.
- W2805226990 cites W2061898713 @default.
- W2805226990 cites W2064689399 @default.
- W2805226990 cites W2068931893 @default.
- W2805226990 cites W2073257981 @default.
- W2805226990 cites W2073882699 @default.
- W2805226990 cites W2075833408 @default.
- W2805226990 cites W2078514191 @default.
- W2805226990 cites W2079111418 @default.
- W2805226990 cites W2086797350 @default.
- W2805226990 cites W2087100948 @default.
- W2805226990 cites W2089790058 @default.
- W2805226990 cites W2091173561 @default.
- W2805226990 cites W2093478617 @default.
- W2805226990 cites W2098549454 @default.
- W2805226990 cites W2105235096 @default.
- W2805226990 cites W2117840333 @default.
- W2805226990 cites W2138011807 @default.
- W2805226990 cites W2160176627 @default.
- W2805226990 cites W2201382378 @default.
- W2805226990 cites W2260052698 @default.
- W2805226990 cites W2281182212 @default.
- W2805226990 cites W2296538017 @default.
- W2805226990 cites W2333577204 @default.
- W2805226990 cites W2346946016 @default.
- W2805226990 cites W2417862864 @default.
- W2805226990 cites W2699220065 @default.
- W2805226990 doi "https://doi.org/10.1038/s41598-018-21517-4" @default.
- W2805226990 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5826934" @default.
- W2805226990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29483516" @default.
- W2805226990 hasPublicationYear "2018" @default.
- W2805226990 type Work @default.
- W2805226990 sameAs 2805226990 @default.
- W2805226990 citedByCount "23" @default.
- W2805226990 countsByYear W28052269902018 @default.
- W2805226990 countsByYear W28052269902019 @default.
- W2805226990 countsByYear W28052269902020 @default.
- W2805226990 countsByYear W28052269902021 @default.
- W2805226990 countsByYear W28052269902022 @default.
- W2805226990 countsByYear W28052269902023 @default.
- W2805226990 crossrefType "journal-article" @default.
- W2805226990 hasAuthorship W2805226990A5012331816 @default.
- W2805226990 hasAuthorship W2805226990A5017082027 @default.
- W2805226990 hasAuthorship W2805226990A5019912186 @default.
- W2805226990 hasAuthorship W2805226990A5029880479 @default.
- W2805226990 hasAuthorship W2805226990A5037078524 @default.
- W2805226990 hasAuthorship W2805226990A5041223114 @default.
- W2805226990 hasAuthorship W2805226990A5052368052 @default.
- W2805226990 hasAuthorship W2805226990A5062088157 @default.
- W2805226990 hasBestOaLocation W28052269901 @default.
- W2805226990 hasConcept C104317684 @default.
- W2805226990 hasConcept C105702510 @default.
- W2805226990 hasConcept C106487976 @default.
- W2805226990 hasConcept C130316041 @default.
- W2805226990 hasConcept C145059251 @default.
- W2805226990 hasConcept C1491633281 @default.
- W2805226990 hasConcept C168240541 @default.
- W2805226990 hasConcept C185592680 @default.
- W2805226990 hasConcept C189165786 @default.